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    Tm2d1 TM2 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362545, updated on 13-Apr-2024

    Summary

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    Symbol
    Tm2d1provided by RGD
    Full Name
    TM2 domain containing 1provided by RGD
    Primary source
    RGD:1305442
    See related
    Ensembl:ENSRNOG00000007527 AllianceGenome:RGD:1305442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bbp
    Summary
    Predicted to enable G protein-coupled receptor activity and amyloid-beta binding activity. Predicted to be involved in apoptotic signaling pathway. Predicted to be integral component of plasma membrane. Orthologous to human TM2D1 (TM2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 44.2), Heart (RPKM 39.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tm2d1 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (118136299..118177639, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (113020793..113062134, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (116992405..117038882, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479010 Neighboring gene ribosomal protein S18-like 5 Neighboring gene PATJ, crumbs cell polarity complex component Neighboring gene uncharacterized LOC134486954 Neighboring gene LINE-1 type transposase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. Kajkowski EM, et al. J Biol Chem, 2001 Jun 1. PMID 11278849
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TM2 domain-containing protein 1
    Names
    beta-amyloid binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108670.2 → NP_001102140.1  TM2 domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_001102140.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JRK6, D3ZYF8
      Related
      ENSRNOP00000009897.5, ENSRNOT00000009897.7
      Conserved Domains (1) summary
      pfam05154
      Location:118 → 167
      TM2; TM2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      118136299..118177639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287946.1 → XP_063144016.1  TM2 domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6JRK6, D3ZYF8

    2. XM_063287944.1 → XP_063144014.1  TM2 domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6JRK6, D3ZYF8

    3. XM_063287945.1 → XP_063144015.1  TM2 domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6JRK6, D3ZYF8

    4. XM_063287947.1 → XP_063144017.1  TM2 domain-containing protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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