grik1a glutamate receptor, ionotropic, kainate 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grik1aprovided by ZNC
Official Full Name: glutamate receptor, ionotropic, kainate 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6502
See related: Ensembl:ENSDARG00000069139 AllianceGenome:ZFIN:ZDB-GENE-030131-6502
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grik1; fv36b03; wu:fv36b03
Summary: Predicted to enable glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within ion transport. Predicted to be located in membrane and synapse. Predicted to be integral component of membrane. Predicted to be active in postsynaptic membrane. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (25403022..25561852, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (25441309..25600136, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor, ionotropic kainate 1; glutamate receptor ionotropic, kainate 1

Names: glutamate receptor, ionotropic, kainate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

25403022..25561852 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305320.3 → XP_009303595.1 glutamate receptor ionotropic, kainate 1 isoform X4

UniProtKB/TrEMBL

A0A8M3B391

Related

ENSDARP00000004703.9, ENSDART00000007778.10

Conserved Domains (4) summary

pfam00060
Location:577 → 846

Lig_chan; Ligand-gated ion channel

pfam01094
Location:57 → 398

ANF_receptor; Receptor family ligand binding region

cl10011
Location:37 → 432

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:446 → 815

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_009305317.3 → XP_009303592.1 glutamate receptor ionotropic, kainate 1 isoform X1

UniProtKB/TrEMBL

A0A8M3BCZ5

Conserved Domains (4) summary

pfam00060
Location:577 → 846

Lig_chan; Ligand-gated ion channel

pfam01094
Location:57 → 398

ANF_receptor; Receptor family ligand binding region

cl10011
Location:37 → 432

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:446 → 815

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_001924003.7 → XP_001924038.3 glutamate receptor ionotropic, kainate 1 isoform X3

UniProtKB/TrEMBL

A0A8M1QKZ5, E9QGN5

Related

ENSDARP00000118019.1, ENSDART00000147089.3

Conserved Domains (4) summary

pfam00060
Location:562 → 831

Lig_chan; Ligand-gated ion channel

pfam01094
Location:57 → 398

ANF_receptor; Receptor family ligand binding region

cl10011
Location:37 → 417

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:431 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_009305319.3 → XP_009303594.1 glutamate receptor ionotropic, kainate 1 isoform X2

See identical proteins and their annotated locations for XP_009303594.1

UniProtKB/TrEMBL

A0A8M3AWP9

Conserved Domains (4) summary

pfam00060
Location:577 → 846

Lig_chan; Ligand-gated ion channel

pfam01094
Location:57 → 398

ANF_receptor; Receptor family ligand binding region

cl10011
Location:37 → 432

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:446 → 815

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_009305318.3 → XP_009303593.1 glutamate receptor ionotropic, kainate 1 isoform X2

See identical proteins and their annotated locations for XP_009303593.1

UniProtKB/TrEMBL

A0A8M3AWP9

Conserved Domains (4) summary

pfam00060
Location:577 → 846

Lig_chan; Ligand-gated ion channel

pfam01094
Location:57 → 398

ANF_receptor; Receptor family ligand binding region

cl10011
Location:37 → 432

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:446 → 815

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily