Scgb3a1 secretoglobin, family 3A, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scgb3a1provided by MGI
Official Full Name: secretoglobin, family 3A, member 1provided by MGI
Primary source: MGI:MGI:1915912
See related: Ensembl:ENSMUSG00000064057 AllianceGenome:MGI:1915912
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HIN-1; Pnsp2; UGRP2; LuLeu2; Utgrp2
Summary: This gene encodes a small secreted protein that may function in the inhibition of cell growth. Expression of the related gene in humans is downregulated via DNA methylation in breast cancers and other tumor types. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Expression: Restricted expression toward lung adult (RPKM 699.5) See more
Orthologs: human all
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Genomic context

Location:: 11 B1.2; 11 29.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (49554422..49555945)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (49663595..49665118)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia
Title: Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia.
Neonatal hyperoxia followed by RA recovery was associated with decreased lung CCSP and SCGB3A1 protein but not mRNA expression.
Title: Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1.
The differential expression of mRNA by both airway level and lung region was determined for uteroglobin-related protein 2.
Title: Site-specific differences in gene expression of secreted proteins in the mouse lung: comparison of methods to show differences by location.
The expression of SCGB3A1 and SCGB3A2 are bidirectionally regulated by oncostatin M (OSM) when examined in a mouse transformed Clara cell line.
Title: Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.
Expression of SCGB3A1 was down-regulated by IFN-gamma in a time- and dose-dependent manner in the murine transformed Clara Cells line.
Title: IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
ubiquitous transcription factor NF-Y binds to and activates expression of the Scgb3a1 gene and tissue-specific expression of the gene is associated with CpG methylation of the promoter
Title: Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression.
Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands
Title: Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues.
EGF-induced increase of Ugrp2 occurred at the transcriptional level that required the EGF receptor and the activation of the ERK-MAPK and phosphoinositide-3 kinase pathways
Title: Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha.
genomic structure and expression patterns of Ugrp2 and its alternative spliced form were characterized
Title: Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Markers

Scgb3a1 (e-PCR), detects polymorphism
- UniSTS:261911

Scgb3a1 (e-PCR), detects polymorphism
- UniSTS:499113

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretoglobin family 3A member 1

Names: cytokine HIN-1; high in normal 1; pneumo secretory protein 2; uteroglobin related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054037.2 → NP_473378.1 secretoglobin family 3A member 1 isoform a precursor

See identical proteins and their annotated locations for NP_473378.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as type A) represents the shorter transcript and encodes the longer isoform (a).

Source sequence(s)

AF313456, AV578532

Consensus CDS

CCDS24619.1

UniProtKB/Swiss-Prot

Q920D7

UniProtKB/TrEMBL

Q5NCL1

Related

ENSMUSP00000043325.4, ENSMUST00000043873.10
NM_170727.2 → NP_733923.1 secretoglobin family 3A member 1 isoform b

See identical proteins and their annotated locations for NP_733923.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as type B) differs in the 5' UTR and contains an alternate exon in the 5' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AF313457, AV578532

Consensus CDS

CCDS36145.1

UniProtKB/TrEMBL

Q8CJC6

Related

ENSMUSP00000075387.5, ENSMUST00000076006.5