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    Mapk15 mitogen-activated protein kinase 15 [ Mus musculus (house mouse) ]

    Gene ID: 332110, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Mapk15provided by MGI
    Official Full Name
    mitogen-activated protein kinase 15provided by MGI
    Primary source
    MGI:MGI:2652894
    See related
    Ensembl:ENSMUSG00000063704 AllianceGenome:MGI:2652894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERK-8
    Summary
    Predicted to enable MAP kinase activity and chromatin binding activity. Involved in positive regulation of metaphase/anaphase transition of meiosis I; positive regulation of spindle assembly; and regulation of cilium assembly. Located in meiotic spindle. Is expressed in several structures, including brain; genitourinary system; limb; nose; and viscerocranium. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 48.8), lung adult (RPKM 26.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mapk15 in Genome Data Viewer
    Location:
    15 D3; 15 35.2 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75865581..75871002)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75993732..75999153)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 707 Neighboring gene coiled-coil domain containing 166 Neighboring gene family with sequence similarity 83, member H Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene scribbled planar cell polarity Neighboring gene microRNA 6952

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The distribution and possible role of ERK8 in mouse oocyte meiotic maturation and early embryo cleavage. Yang SW, et al. Microsc Microanal, 2013 Feb. PMID 23351492
    2. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. Xu YM, et al. Cancer Res, 2010 Apr 15. PMID 20395206
    3. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. Iavarone C, et al. J Biol Chem, 2006 Apr 14. PMID 16484222
    4. ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled. Miyatake K, et al. Nat Commun, 2015 Mar 31. PMID 25823377
    5. Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity. Rossi M, et al. J Biol Chem, 2011 Mar 11. PMID 21190936, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.
      Title: The distribution and possible role of ERK8 in mouse oocyte meiotic maturation and early embryo cleavage.
    2. a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor.
      Title: Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.
    3. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
      Title: Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
    4. Erk8 has a role as a novel effector of RET/PTC3 and, therefore, RET biological functions
      Title: Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56865, MGC56903

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dopamine uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of metaphase/anaphase transition of meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estradiol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 15
    Names
    ERK-7
    MAP kinase 15
    MAPK 15
    extracellular signal-regulated kinase 7
    extracellular signal-regulated kinase 8
    NP_001403335.1
    NP_001403336.1
    NP_001403337.1
    NP_808590.1
    XP_006521162.1
    XP_006521163.1
    XP_006521164.1
    XP_006521165.1
    XP_006521166.1
    XP_006521167.1
    XP_006521169.1
    XP_011243980.1
    XP_011243981.1
    XP_017172159.1
    XP_017172160.1
    XP_030104475.1
    XP_030104476.1
    XP_036015365.1
    XP_036015366.1
    XP_036015367.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416406.1 → NP_001403335.1  mitogen-activated protein kinase 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116487

    2. NM_001416407.1 → NP_001403336.1  mitogen-activated protein kinase 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116487

    3. NM_001416408.1 → NP_001403337.1  mitogen-activated protein kinase 15 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116487

    4. NM_177922.3 → NP_808590.1  mitogen-activated protein kinase 15 isoform 1

      See identical proteins and their annotated locations for NP_808590.1

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Consensus CDS
      CCDS27558.1
      UniProtKB/Swiss-Prot
      Q80Y86
      Related
      ENSMUSP00000087098.5, ENSMUST00000089669.6
      Conserved Domains (2) summary
      smart00220
      Location:14 → 305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:6 → 344
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75865581..75871002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521104.4 → XP_006521167.1  mitogen-activated protein kinase 15 isoform X6

      See identical proteins and their annotated locations for XP_006521167.1

      Conserved Domains (1) summary
      cd07852
      Location:6 → 374
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    2. XM_006521103.3 → XP_006521166.1  mitogen-activated protein kinase 15 isoform X6

      See identical proteins and their annotated locations for XP_006521166.1

      Conserved Domains (1) summary
      cd07852
      Location:6 → 374
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    3. XM_006521106.3 → XP_006521169.1  mitogen-activated protein kinase 15 isoform X8

      Conserved Domains (1) summary
      cd07852
      Location:6 → 344
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    4. XM_006521099.3 → XP_006521162.1  mitogen-activated protein kinase 15 isoform X1

      Conserved Domains (1) summary
      cd07852
      Location:6 → 374
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    5. XM_006521101.3 → XP_006521164.1  mitogen-activated protein kinase 15 isoform X3

      Conserved Domains (1) summary
      cd07852
      Location:6 → 364
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    6. XM_011245678.4 → XP_011243980.1  mitogen-activated protein kinase 15 isoform X12

    7. XM_011245679.4 → XP_011243981.1  mitogen-activated protein kinase 15 isoform X13

    8. XM_006521100.3 → XP_006521163.1  mitogen-activated protein kinase 15 isoform X2

      Conserved Domains (1) summary
      cd07852
      Location:6 → 374
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    9. XM_006521102.3 → XP_006521165.1  mitogen-activated protein kinase 15 isoform X4

      Conserved Domains (1) summary
      cd07852
      Location:6 → 344
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    10. XM_030248615.2 → XP_030104475.1  mitogen-activated protein kinase 15 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:58 → 237
      PKc_like; Protein Kinases, catalytic domain

    11. XM_030248616.2 → XP_030104476.1  mitogen-activated protein kinase 15 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:58 → 237
      PKc_like; Protein Kinases, catalytic domain

    12. XM_036159473.1 → XP_036015366.1  mitogen-activated protein kinase 15 isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:58 → 207
      PKc_like; Protein Kinases, catalytic domain

    13. XM_017316671.3 → XP_017172160.1  mitogen-activated protein kinase 15 isoform X14

      Conserved Domains (1) summary
      cl21453
      Location:58 → 207
      PKc_like; Protein Kinases, catalytic domain

    14. XM_017316670.3 → XP_017172159.1  mitogen-activated protein kinase 15 isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:58 → 207
      PKc_like; Protein Kinases, catalytic domain

    15. XM_036159474.1 → XP_036015367.1  mitogen-activated protein kinase 15 isoform X10

      Conserved Domains (1) summary
      cl21453
      Location:58 → 207
      PKc_like; Protein Kinases, catalytic domain

    16. XM_036159472.1 → XP_036015365.1  mitogen-activated protein kinase 15 isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:58 → 207
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_384020.3 RNA Sequence

    2. XR_004938843.1 RNA Sequence

    3. XR_004938844.1 RNA Sequence

    4. XR_004938845.1 RNA Sequence

    5. XR_003951401.2 RNA Sequence

    6. XR_004938846.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y86.1 GenPept UniProtKB/Swiss-Prot:Q80Y86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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