Rangrf RAN guanine nucleotide release factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rangrfprovided by MGI
Official Full Name: RAN guanine nucleotide release factorprovided by MGI
Primary source: MGI:MGI:1889073
See related: Ensembl:ENSMUSG00000032892 AllianceGenome:MGI:1889073
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mog1; Rangnrf; 2400006H24Rik
Summary: Enables several functions, including guanyl-nucleotide exchange factor activity; small GTPase binding activity; and transmembrane transporter binding activity. Involved in regulation of membrane depolarization and regulation of sodium ion transmembrane transporter activity. Located in intercalated disc and nucleoplasm. Is expressed in central nervous system; retina; retina ganglion cell layer; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human RANGRF (RAN guanine nucleotide release factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 259.2), heart adult (RPKM 33.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.24 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (68863310..68866011, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (68972484..68975185, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling.
Title: Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling.
in cardiomyocytes, MOG1 is mostly localized in the cell membrane and co-localized with Nav1.5, indicating that MOG1 is a critical regulator of sodium channel function in the heart
Title: Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in heart contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleocytoplasmic transport	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein exit from endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of sodium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ran guanine nucleotide release factor

Names: ran-binding protein MOG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285441.1 → NP_001272370.1 ran guanine nucleotide release factor isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL603662, BC087921, BX523534

UniProtKB/Swiss-Prot

Q9JIB0

Related

ENSMUST00000150017.8

Conserved Domains (1) summary

cd00224
Location:35 → 191

Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
NM_001285442.1 → NP_001272371.1 ran guanine nucleotide release factor isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

BB618250, BX523534, BY775054, CF751505

Conserved Domains (1) summary

cd00224
Location:7 → 176

Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
NM_001285443.1 → NP_001272372.1 ran guanine nucleotide release factor isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

BB618250, BC087921, BX523534, BY775054

UniProtKB/Swiss-Prot

Q9JIB0

Conserved Domains (1) summary

cd00224
Location:7 → 180

Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
NM_021329.3 → NP_067304.1 ran guanine nucleotide release factor isoform 2

See identical proteins and their annotated locations for NP_067304.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

BB618250, BC087921, BX523534, BY775054

Consensus CDS

CCDS24875.1

UniProtKB/Swiss-Prot

Q9CWZ0, Q9JIB0

Related

ENSMUSP00000038485.5, ENSMUST00000038644.5

Conserved Domains (1) summary

cd00224
Location:7 → 183

Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)