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    Bclaf3 Bclaf1 and Thrap3 family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 382252, updated on 12-May-2024

    Summary

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    Official Symbol
    Bclaf3provided by MGI
    Official Full Name
    Bclaf1 and Thrap3 family member 3provided by MGI
    Primary source
    MGI:MGI:2685992
    See related
    Ensembl:ENSMUSG00000044150 AllianceGenome:MGI:2685992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1146; 2310067E24Rik; A830080D01Rik
    Summary
    Predicted to enable DNA binding activity and transcription coregulator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be part of mediator complex. Is expressed in central nervous system and retina. Orthologous to human BCLAF3 (BCLAF1 and THRAP3 family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 7.7), CNS E14 (RPKM 4.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bclaf3 in Genome Data Viewer
    Location:
    X F4; X 73.55 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (158315639..158376077)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (159532642..159593081)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene MAP7 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_48172 Neighboring gene STARR-seq mESC enhancer starr_48173 Neighboring gene STARR-seq mESC enhancer starr_48174 Neighboring gene STARR-positive B cell enhancer mm9_chrX:155970286-155970586 Neighboring gene predicted gene, 39546 Neighboring gene hepatitis B virus x interacting protein pseudogene Neighboring gene predicted gene 15186 Neighboring gene STARR-positive B cell enhancer mm9_chrX:156088144-156088445 Neighboring gene SH3-domain kinase binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:156134996-156135149 Neighboring gene STARR-seq mESC enhancer starr_48175 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene cofilin 1, non-muscle pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1. Chakraborty D, et al. Cell Rep, 2017 Dec 12. PMID 29241531
    2. A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells. Murakami K, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479180, Free PMC Article
    3. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
      Title: A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
    2. lncRNA Panct1 maintains mouse embryonic stem cell identity by regulating TOBF1 recruitment to Oct-Sox sequences in early G1.
      Title: lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BCLAF1 and THRAP3 family member 3
    Names
    uncharacterized protein CXorf23 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033472.2 → NP_001028644.2  BCLAF1 and THRAP3 family member 3 isoform 1

      See identical proteins and their annotated locations for NP_001028644.2

      Status: VALIDATED

      Source sequence(s)
      AL672284, BC075674
      Consensus CDS
      CCDS30503.2
      UniProtKB/Swiss-Prot
      A2AG56, A2AG57, A2AG58, Q3UM32, Q8BRL2
      Related
      ENSMUSP00000108083.2, ENSMUST00000112464.8
      Conserved Domains (1) summary
      pfam15440
      Location:12 → 631
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    2. NM_001358939.1 → NP_001345868.1  BCLAF1 and THRAP3 family member 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672284
      Conserved Domains (1) summary
      pfam15440
      Location:3 → 665
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    3. NM_001358940.1 → NP_001345869.1  BCLAF1 and THRAP3 family member 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672284
      Conserved Domains (1) summary
      pfam15440
      Location:3 → 666
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    4. NM_001358941.1 → NP_001345870.1  BCLAF1 and THRAP3 family member 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672284
      Conserved Domains (1) summary
      pfam15440
      Location:3 → 665
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    5. NM_001358942.1 → NP_001345871.1  BCLAF1 and THRAP3 family member 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL672284
      Consensus CDS
      CCDS90769.1
      Related
      ENSMUSP00000051031.7, ENSMUST00000057180.13
      Conserved Domains (1) summary
      pfam15440
      Location:3 → 590
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RNA

    1. NR_152562.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672284

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      158315639..158376077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247837.3 → XP_011246139.1  BCLAF1 and THRAP3 family member 3 isoform X1

      Conserved Domains (1) summary
      pfam15440
      Location:3 → 637
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    2. XM_017318534.3 → XP_017174023.1  BCLAF1 and THRAP3 family member 3 isoform X2

      UniProtKB/Swiss-Prot
      A2AG58
      Conserved Domains (1) summary
      pfam15440
      Location:3 → 590
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RNA

    1. XR_004940348.1 RNA Sequence

    2. XR_004940350.1 RNA Sequence

    3. XR_004940351.1 RNA Sequence

    4. XR_004940349.1 RNA Sequence

    5. XR_003953013.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AG58.1 GenPept UniProtKB/Swiss-Prot:A2AG58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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