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    rasgef1ba RasGEF domain family, member 1Ba [ Danio rerio (zebrafish) ]

    Gene ID: 327572, updated on 11-Apr-2024

    Summary

    Official Symbol
    rasgef1baprovided by ZNC
    Official Full Name
    RasGEF domain family, member 1Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5783
    See related
    Ensembl:ENSDARG00000033614 AllianceGenome:ZFIN:ZDB-GENE-030131-5783
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rasgef1b; zgc:66487; wu:fi18a09
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Is expressed in several structures, including axis; forerunner cell group; germ ring; mesoderm; and nervous system. Orthologous to human RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
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    Genomic context

    See rasgef1ba in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (39707311..39805629, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (39107158..39205480, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 299 Neighboring gene bone morphogenetic protein 3 Neighboring gene protein kinase cGMP-dependent 2 Neighboring gene serine/threonine-protein kinase pim-2-like Neighboring gene uncharacterized LOC103911096

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ras-GEF domain-containing family member 1B-A
    Names
    RasGEF domain family, member 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199829.1NP_956123.1  ras-GEF domain-containing family member 1B-A

      See identical proteins and their annotated locations for NP_956123.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055678
      UniProtKB/Swiss-Prot
      Q6DHR3
      Conserved Domains (2) summary
      cd06224
      Location:43167
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:209403
      RasGEF; RasGEF domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      39707311..39805629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165279.4XP_005165336.1  ras-GEF domain-containing family member 1B-A isoform X2

      See identical proteins and their annotated locations for XP_005165336.1

      UniProtKB/Swiss-Prot
      A2AVJ1, Q6DHR3, Q7SXB0
      Related
      ENSDARP00000116417.1, ENSDART00000137801.2
      Conserved Domains (2) summary
      cd06224
      Location:84208
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:250444
      RasGEF; RasGEF domain
    2. XM_005165278.4XP_005165335.1  ras-GEF domain-containing family member 1B-A isoform X1

      UniProtKB/TrEMBL
      A0A286YBK7, A0A8M2BCQ2
      Related
      ENSDARP00000144585.1, ENSDART00000176202.2
      Conserved Domains (2) summary
      cd06224
      Location:101225
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:267461
      RasGEF; RasGEF domain
    3. XM_005165280.4XP_005165337.1  ras-GEF domain-containing family member 1B-A isoform X3

      See identical proteins and their annotated locations for XP_005165337.1

      UniProtKB/Swiss-Prot
      Q6DHR3
      Related
      ENSDARP00000110368.2, ENSDART00000127123.4
      Conserved Domains (2) summary
      cd06224
      Location:43167
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:209403
      RasGEF; RasGEF domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394599.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      348293..445525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)