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    ppil1 peptidylprolyl isomerase (cyclophilin)-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 558042, updated on 19-May-2024

    Summary

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    Official Symbol
    ppil1provided by ZNC
    Official Full Name
    peptidylprolyl isomerase (cyclophilin)-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051009-1
    See related
    Ensembl:ENSDARG00000015422 AllianceGenome:ZFIN:ZDB-GENE-051009-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:123245
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to act upstream of or within protein folding. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human PPIL1 (peptidylprolyl isomerase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See ppil1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40647788..40651935, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40650252..40654399, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene solute carrier family 6 member 11a Neighboring gene microRNA 429b Neighboring gene microRNA 141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC123245

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase-like 1
    NP_001029350.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034178.2 → NP_001029350.1  peptidyl-prolyl cis-trans isomerase-like 1

      See identical proteins and their annotated locations for NP_001029350.1

      Status: VALIDATED

      Source sequence(s)
      CU855953
      UniProtKB/TrEMBL
      A0A8M1N7V1, Q3KR14
      Related
      ENSDARP00000156272.1, ENSDART00000187423.1
      Conserved Domains (1) summary
      cl00197
      Location:16 → 161
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    2. NM_001423703.1 → NP_001410632.1  peptidyl-prolyl cis-trans isomerase-like 1

      Status: VALIDATED

      Source sequence(s)
      CU855953
      UniProtKB/TrEMBL
      A0A8M1N7V1, Q3KR14

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      40647788..40651935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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