nsfl1c NSFL1 (p97) cofactor (p47) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nsfl1cprovided by ZNC
Official Full Name: NSFL1 (p97) cofactor (p47)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-160
See related: Ensembl:ENSDARG00000087640 AllianceGenome:ZFIN:ZDB-GENE-041114-160
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zehn2383; wu:fc88f08; zgc:101636; hm:zehn2383
Summary: Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi stack. Predicted to be active in cytosol and nucleus. Orthologous to human NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (18794832..18805565, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (18868489..18879222, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear membrane reassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NSFL1 cofactor p47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007446.1 → NP_001007447.1 NSFL1 cofactor p47

See identical proteins and their annotated locations for NP_001007447.1

Status: PROVISIONAL

Source sequence(s)

BC085395

UniProtKB/TrEMBL

Q5U3U1

Related

ENSDARP00000115283.1, ENSDART00000143065.3

Conserved Domains (3) summary

cd01770
Location:294 → 372

p47_UBX; p47-like ubiquitin domain

smart00553
Location:181 → 270

SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47

cd14348
Location:5 → 44

UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

18794832..18805565 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009296732.1 → XP_009295007.1 NSFL1 cofactor p47 isoform X1

UniProtKB/TrEMBL

A0A8M3AV68

Conserved Domains (3) summary

cd01770
Location:293 → 371

p47_UBX; p47-like ubiquitin domain

smart00553
Location:178 → 269

SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47

cd14348
Location:5 → 44

UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins
XM_021469793.1 → XP_021325468.1 NSFL1 cofactor p47 isoform X2

UniProtKB/TrEMBL

A0A8M9PF11

Conserved Domains (2) summary

cd14348
Location:5 → 44

UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins

cl02662
Location:178 → 216

SEP; SEP domain