ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif 6 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ADAMTS6provided by VGNC
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 6provided by VGNC
Primary source: VGNC:VGNC:25628
See related: BGD:BT25742; Ensembl:ENSBTAG00000016963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	20	NC_037347.1 (14055308..14485041)

Chromosome 20 - NC_037347.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH142611 (e-PCR)
- UniSTS:231858

CC523832 (e-PCR)
- UniSTS:476639

RM310 (e-PCR), detects polymorphism
- UniSTS:29156

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193016.1 → NP_001179945.1 A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor

See identical proteins and their annotated locations for NP_001179945.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000020

UniProtKB/TrEMBL

E1BK03

Related

ENSBTAP00000053837.2, ENSBTAT00000061189.4

Conserved Domains (5) summary

smart00209
Location:561 → 613

TSP1; Thrombospondin type 1 repeats

cd04273
Location:250 → 465

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:43 → 191

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:719 → 829

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1083 → 1115

PLAC; PLAC (protease and lacunin) domain