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    hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 [ Danio rerio (zebrafish) ]

    Gene ID: 450078, updated on 27-Mar-2024

    Summary

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    Official Symbol
    hsd17b10provided by ZNC
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-201
    See related
    Ensembl:ENSDARG00000017781 AllianceGenome:ZFIN:ZDB-GENE-041010-201
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hadh2; im:6899159; wu:fj61f03; zgc:101605
    Summary
    Predicted to enable estradiol 17-beta-dehydrogenase activity. Predicted to be involved in androgen metabolic process; estrogen metabolic process; and fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in central nervous system; endoderm; head; immature eye; and paraxial mesoderm. Human ortholog(s) of this gene implicated in chromosome Xp11.22 duplication syndrome; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See hsd17b10 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (18372048..18381360, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (18445705..18455017, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene protein FAM19A4-like Neighboring gene TAFA chemokine like family member 1a Neighboring gene microRNA let7g-1 Neighboring gene family with sequence similarity 120 member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Xiao L, et al. Front Genet, 2020. PMID 32194632, Free PMC Article
    2. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyacyl-CoA dehydrogenase type-2
    Names
    hydroxyacyl-Coenzyme A dehydrogenase, type II
    NP_001006098.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006098.1 → NP_001006098.1  3-hydroxyacyl-CoA dehydrogenase type-2

      See identical proteins and their annotated locations for NP_001006098.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083219
      UniProtKB/TrEMBL
      B2GRT3, Q5XJS8
      Related
      ENSDARP00000017597.4, ENSDART00000016891.6
      Conserved Domains (2) summary
      cd05371
      Location:8 → 260
      HSD10-like_SDR_c; 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs
      PRK05557
      Location:6 → 259
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      18372048..18381360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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