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    Slc45a4 solute carrier family 45, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 106068, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc45a4provided by MGI
    Official Full Name
    solute carrier family 45, member 4provided by MGI
    Primary source
    MGI:MGI:2146236
    See related
    Ensembl:ENSMUSG00000079020 AllianceGenome:MGI:2146236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9330175B01Rik
    Summary
    Enables sucrose:proton symporter activity. Acts upstream of or within sucrose transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in central nervous system and retina. Orthologous to human SLC45A4 (solute carrier family 45 member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 15.9), ovary adult (RPKM 14.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc45a4 in Genome Data Viewer
    Location:
    15 D3; 15 34.02 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (73449267..73517606, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (73577418..73645757, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:73342795-73343096 Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial pseudogene Neighboring gene DENN domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_38965 Neighboring gene STARR-positive B cell enhancer mm9_chr15:73476060-73476361 Neighboring gene STARR-seq mESC enhancer starr_38967 Neighboring gene STARR-seq mESC enhancer starr_38972 Neighboring gene G protein-coupled receptor 20 Neighboring gene STARR-positive B cell enhancer mm9_chr15:73548453-73548754 Neighboring gene protein tyrosine phosphatase 4a3 Neighboring gene predicted gene, 22106

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain. Suenkel C, et al. Cell Rep, 2020 Feb 18. PMID 32075758
    2. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. Bartölke R, et al. Biochem J, 2014 Dec 1. PMID 25164149
    3. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    4. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within sucrose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 45 member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033219.4 → NP_001028391.2  solute carrier family 45 member 4 isoform 1

      See identical proteins and their annotated locations for NP_001028391.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC119914
      Consensus CDS
      CCDS27517.1
      UniProtKB/Swiss-Prot
      Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
      UniProtKB/TrEMBL
      F7BEQ1
      Related
      ENSMUSP00000121775.2, ENSMUST00000151288.8
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily

    2. NM_001168255.2 → NP_001161727.1  solute carrier family 45 member 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC119914
      Consensus CDS
      CCDS49632.1
      UniProtKB/TrEMBL
      F7BEQ1
      Related
      ENSMUSP00000115827.2, ENSMUST00000132607.2
      Conserved Domains (1) summary
      cd06174
      Location:386 → 537
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    3. NM_001357747.1 → NP_001344676.1  solute carrier family 45 member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC119914
      Consensus CDS
      CCDS27517.1
      UniProtKB/Swiss-Prot
      Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
      UniProtKB/TrEMBL
      F7BEQ1
      Related
      ENSMUSP00000075577.6, ENSMUST00000076224.12
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      73449267..73517606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245401.1 → XP_011243703.1  solute carrier family 45 member 4 isoform X1

      See identical proteins and their annotated locations for XP_011243703.1

      UniProtKB/Swiss-Prot
      Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
      UniProtKB/TrEMBL
      F7BEQ1
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily

    2. XM_017316363.3 → XP_017171852.1  solute carrier family 45 member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
      UniProtKB/TrEMBL
      F7BEQ1
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily

    3. XM_030248266.2 → XP_030104126.1  solute carrier family 45 member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
      UniProtKB/TrEMBL
      F7BEQ1
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily

    4. XM_017316364.3 → XP_017171853.1  solute carrier family 45 member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q0P5V9, Q3TCG5, Q3V0B8, Q69ZR4, Q6PDG3
      UniProtKB/TrEMBL
      F7BEQ1
      Conserved Domains (1) summary
      cl28910
      Location:53 → 275
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P5V9.1 GenPept UniProtKB/Swiss-Prot:Q0P5V9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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