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    Ankfn1 ankyrin-repeat and fibronectin type III domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 382543, updated on 12-May-2024

    Summary

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    Official Symbol
    Ankfn1provided by MGI
    Official Full Name
    ankyrin-repeat and fibronectin type III domain containing 1provided by MGI
    Primary source
    MGI:MGI:2686021
    See related
    Ensembl:ENSMUSG00000047773 AllianceGenome:MGI:2686021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nmf9; mWAKE; Gm1175; 4932411E22Rik
    Summary
    Acts upstream of or within behavioral fear response; equilibrioception; and locomotor rhythm. Predicted to be active in spindle. Orthologous to human ANKFN1 (ankyrin repeat and fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 7.9), CNS E18 (RPKM 1.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankfn1 in Genome Data Viewer
    Location:
    11 C; 11 54.34 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (89280918..89668727, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (89390092..89777901, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene noggin Neighboring gene predicted gene, 42088 Neighboring gene STARR-seq mESC enhancer starr_30401 Neighboring gene STARR-seq mESC enhancer starr_30402 Neighboring gene STARR-seq mESC enhancer starr_30405 Neighboring gene STARR-seq mESC enhancer starr_30406 Neighboring gene predicted gene, 34619 Neighboring gene predicted gene, 34677 Neighboring gene STARR-positive B cell enhancer ABC_E2364 Neighboring gene phosphatidylcholine transfer protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of mWake expression in the murine brain. Bell BJ, et al. J Comp Neurol, 2021 Jun. PMID 33140455, Free PMC Article
    2. Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice. Concepcion D, et al. Genetics, 2004 Oct. PMID 15514066, Free PMC Article
    3. Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies. Zhang S, et al. PLoS Genet, 2015 Jul. PMID 26131556, Free PMC Article
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (5)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC175922

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within equilibrioception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of bipolar cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin-repeat and fibronectin type III domain-containing 1
    Names
    ankyrin repeat and fibronectin type-III domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327810.1 → NP_001314739.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645903, AL662930, AL672175, AL672280, AL772375
      UniProtKB/TrEMBL
      A0A140LIW7
      Related
      ENSMUSP00000158789.2, ENSMUST00000238273.3

    2. NM_172534.2 → NP_766122.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform 2

      See identical proteins and their annotated locations for NP_766122.1

      Status: VALIDATED

      Source sequence(s)
      AK029964
      Consensus CDS
      CCDS25237.1
      UniProtKB/TrEMBL
      B2KGG3, Q8CDJ6
      Related
      ENSMUSP00000049776.2, ENSMUST00000050983.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      89280918..89668727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246107.1 → XP_030101967.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1

      UniProtKB/TrEMBL
      A0A140LIW7
      Conserved Domains (3) summary
      cd00063
      Location:222 → 293
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00045
      Location:66 → 100
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:70 → 123
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_017314636.3 → XP_017170125.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1

      UniProtKB/TrEMBL
      A0A140LIW7
      Related
      ENSMUSP00000146987.2, ENSMUST00000207815.2
      Conserved Domains (3) summary
      cd00063
      Location:222 → 293
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00045
      Location:66 → 100
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:70 → 123
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_030246105.2 → XP_030101965.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1

      UniProtKB/TrEMBL
      A0A140LIW7
      Conserved Domains (3) summary
      cd00063
      Location:222 → 293
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00045
      Location:66 → 100
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:70 → 123
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_030246106.2 → XP_030101966.1  ankyrin-repeat and fibronectin type III domain-containing 1 isoform X1

      UniProtKB/TrEMBL
      A0A140LIW7
      Conserved Domains (3) summary
      cd00063
      Location:222 → 293
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00045
      Location:66 → 100
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:70 → 123
      Ank_2; Ankyrin repeats (3 copies)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080933.1: Suppressed sequence

      Description
      NM_001080933.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A571BF63.1 GenPept UniProtKB/Swiss-Prot:A0A571BF63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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