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    Veph1 ventricular zone expressed PH domain-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 72789, updated on 8-May-2024

    Summary

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    Official Symbol
    Veph1provided by MGI
    Official Full Name
    ventricular zone expressed PH domain-containing 1provided by MGI
    Primary source
    MGI:MGI:1920039
    See related
    Ensembl:ENSMUSG00000027831 AllianceGenome:MGI:1920039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Veph; 2810471M23Rik
    Summary
    Predicted to enable phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; eye; and metanephros. Orthologous to human VEPH1 (ventricular zone expressed PH domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 2.2), CNS E11.5 (RPKM 0.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 E1; 3 30.25 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (65960979..66204370, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (66053558..66296974, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07874 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 26442 Neighboring gene triosephosphate isomerase related sequence 2 Neighboring gene predicted gene, 54199 Neighboring gene pentraxin related gene Neighboring gene STARR-seq mESC enhancer starr_07875 Neighboring gene STARR-seq mESC enhancer starr_07876 Neighboring gene predicted gene, 35184 Neighboring gene predicted gene, 35236

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice. Shi X, et al. Lab Invest, 2020 Dec. PMID 32612287
    2. Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling. Shathasivam P, et al. Proc Natl Acad Sci U S A, 2015 Jun 9. PMID 26039994, Free PMC Article
    3. Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. Muto E, et al. Biochimie, 2004 Aug. PMID 15388229
    4. PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors. He L, et al. Development, 2021 Mar 17. PMID 33597191, Free PMC Article
    5. Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dasgupta K, et al. Dev Biol, 2019 Nov 15. PMID 31351040, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice.
      Title: MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice.
    2. Veph was strongly expressed in the ventricular zone of the embryonic brain, and its expression level gradually decreased in later stages.
      Title: Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-5-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ventricular zone-expressed PH domain-containing protein 1
    Names
    protein melted homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145820.3 → NP_665819.2  ventricular zone-expressed PH domain-containing protein 1

      See identical proteins and their annotated locations for NP_665819.2

      Status: VALIDATED

      Source sequence(s)
      AC098705, AC121312, BC075649
      Consensus CDS
      CCDS17391.1
      UniProtKB/Swiss-Prot
      A1A535, E9QP23, Q8K4P5, Q8K4P6, Q9CYR8
      Related
      ENSMUSP00000029419.7, ENSMUST00000029419.8
      Conserved Domains (2) summary
      cd01264
      Location:716 → 824
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain
      pfam00169
      Location:717 → 819
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      65960979..66204370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502143.5 → XP_006502206.1  ventricular zone-expressed PH domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cd01264
      Location:680 → 788
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

    2. XM_006502142.5 → XP_006502205.1  ventricular zone-expressed PH domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006502205.1

      Conserved Domains (1) summary
      cd01264
      Location:750 → 858
      PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028357.4: Suppressed sequence

      Description
      NM_028357.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1A535.2 GenPept UniProtKB/Swiss-Prot:A1A535

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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