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    Zfp870 zinc finger protein 870 [ Mus musculus (house mouse) ]

    Gene ID: 240066, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp870provided by MGI
    Official Full Name
    zinc finger protein 870provided by MGI
    Primary source
    MGI:MGI:3029586
    See related
    Ensembl:ENSMUSG00000095325 AllianceGenome:MGI:3029586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in nervous system and neural retina. Orthologous to human ZNF670 (zinc finger protein 670). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.6), CNS E18 (RPKM 1.4) and 26 other tissues See more
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    Genomic context

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    See Zfp870 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33098193..33110621, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32879221..32891641, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7059 Neighboring gene predicted gene, 50050 Neighboring gene STARR-seq mESC enhancer starr_42396 Neighboring gene zinc finger protein 870 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33028261-33028519 Neighboring gene STARR-seq mESC enhancer starr_42399 Neighboring gene STARR-seq mESC enhancer starr_42400 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 14 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33084248-33084483

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC86136

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 870

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425928.1 → NP_001412857.1  zinc finger protein 870 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT033772

    2. NM_207245.3 → NP_997128.1  zinc finger protein 870 isoform 2

      See identical proteins and their annotated locations for NP_997128.1

      Status: VALIDATED

      Source sequence(s)
      CT033772
      Consensus CDS
      CCDS89069.1
      UniProtKB/TrEMBL
      Q6NZJ3
      Related
      ENSMUSP00000154207.2, ENSMUST00000228075.3
      Conserved Domains (6) summary
      smart00349
      Location:4 → 53
      KRAB; krueppel associated box
      COG5048
      Location:360 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:376 → 399
      zf-H2C2_2; Zinc-finger double domain
      cl19284
      Location:265 → 321
      Ribosomal_L37ae; Ribosomal L37ae protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33098193..33110621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160603.1 → XP_036016496.1  zinc finger protein 870 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:206 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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