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    Zfp970 zinc finger protein 970 [ Mus musculus (house mouse) ]

    Gene ID: 628308, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp970provided by MGI
    Official Full Name
    zinc finger protein 970provided by MGI
    Primary source
    MGI:MGI:3652255
    See related
    Ensembl:ENSMUSG00000078866 AllianceGenome:MGI:3652255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm14420
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF101 (zinc finger protein 101); ZNF28 (zinc finger protein 28); and ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.3), cerebellum adult (RPKM 4.3) and 25 other tissues See more
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    Genomic context

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    See Zfp970 in Genome Data Viewer
    Location:
    2 H4; 2 99.38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (177156096..177170987)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (177464742..177479194)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568489 Neighboring gene STARR-seq mESC enhancer starr_06678 Neighboring gene STARR-seq mESC enhancer starr_06679 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06680 Neighboring gene predicted gene 14403 Neighboring gene STARR-seq mESC enhancer starr_06681 Neighboring gene STARR-seq mESC enhancer starr_06682 Neighboring gene novel KRAB box and zinc finger, C2H2 type domain containing protein Neighboring gene STARR-seq mESC enhancer starr_06683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KRAB box and zinc finger C2H2 type domain containing protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177568.1 → NP_001171039.1  KRAB box and zinc finger C2H2 type domain containing protein-like

      See identical proteins and their annotated locations for NP_001171039.1

      Status: VALIDATED

      Source sequence(s)
      AL845468, BX294394
      Consensus CDS
      CCDS50831.1
      UniProtKB/TrEMBL
      F7CWF0, Q08BU3
      Related
      ENSMUSP00000104580.4, ENSMUST00000108952.4
      Conserved Domains (5) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      COG5048
      Location:75 → 477
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      177156096..177170987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162441.1 → XP_036018334.1  KRAB box and zinc finger C2H2 type domain containing protein-like isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:43 → 445
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:409 → 429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:450 → 474
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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