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    Ftl2-ps ferritin light polypeptide 2, pseudogene [ Mus musculus (house mouse) ]

    Gene ID: 14337, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ftl2-psprovided by MGI
    Official Full Name
    ferritin light polypeptide 2, pseudogeneprovided by MGI
    Primary source
    MGI:MGI:95590
    See related
    AllianceGenome:MGI:95590
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftl; Ftl2; Ftl-2
    Summary
    Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Ftl2-ps in Genome Data Viewer
    Location:
    4 D2.2; 4 58.94 cM
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125397873..125398811)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125504080..125505018)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40247 Neighboring gene STARR-seq mESC enhancer starr_11366 Neighboring gene predicted gene, 32756 Neighboring gene STARR-seq mESC enhancer starr_11372 Neighboring gene glutamate receptor, ionotropic, kainate 3 Neighboring gene microRNA 692-2 Neighboring gene STARR-seq mESC enhancer starr_11375 Neighboring gene predicted gene, 32807 Neighboring gene predicted gene, 54257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A second ferritin L subunit is encoded by an intronless gene in the mouse. Renaudie F, et al. Mamm Genome, 1992. PMID 1543909
    2. Role of H and L subunits in mouse ferritin. Rucker P, et al. J Biol Chem, 1996 Dec 27. PMID 8969195
    3. Expression of H and L ferritin mRNAs in mouse small intestine. Gérard B, et al. Exp Cell Res, 1996 Oct 10. PMID 8892964
    4. Cellular distribution of iron, transferrin, and ferritin in the hypotransferrinemic (Hp) mouse brain. Dickinson TK, et al. J Comp Neurol, 1995 Apr 24. PMID 7636015
    5. Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Iacovelli J, et al. Brain Res, 2009 Sep 15. PMID 19596281, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Other Names

    • ferritin L subunit 2
    • ferritin light chain 2, pseudogene
    • ferritin subunit LG

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular sequestering of iron ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intracellular ferritin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029382.1 

      Range
      101..1039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      125397873..125398811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_008049.2: Suppressed sequence

      Description
      NM_008049.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49945.2 GenPept UniProtKB/Swiss-Prot:P49945

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.