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    Trim11 tripartite motif-containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 94091, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trim11provided by MGI
    Official Full Name
    tripartite motif-containing 11provided by MGI
    Primary source
    MGI:MGI:2137355
    See related
    Ensembl:ENSMUSG00000020455 AllianceGenome:MGI:2137355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein domain specific binding activity and ubiquitin protein ligase activity. Involved in several processes, including defense response to other organism; negative regulation of viral transcription; and regulation of viral entry into host cell. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; liver; nervous system; and urinary system. Orthologous to human TRIM11 (tripartite motif containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 23.0), spleen adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim11 in Genome Data Viewer
    Location:
    11 B1.3; 11 36.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58865054..58882288)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58973726..58991462)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E114 Neighboring gene STARR-positive B cell enhancer ABC_E5230 Neighboring gene STARR-positive B cell enhancer ABC_E6989 Neighboring gene RIKEN cDNA 2310058D17 gene Neighboring gene H2A clustered histone 25 Neighboring gene tripartite motif-containing 17 Neighboring gene STARR-seq mESC enhancer starr_29613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58796334-58796535 Neighboring gene H3.4 histone, cluster member Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene predicted gene 10435 Neighboring gene STARR-seq mESC enhancer starr_29614 Neighboring gene STARR-positive B cell enhancer ABC_E5231 Neighboring gene IBA57 homolog, iron-sulfur cluster assembly

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of KDM5C stability and enhancer reprogramming in breast cancer. Xiao Q, et al. Cell Death Dis, 2022 Oct 3. PMID 36192394, Free PMC Article
    2. General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Matta JA, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18574153, Free PMC Article
    3. A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Niikura T, et al. Eur J Neurosci, 2003 Mar. PMID 12670303
    4. TRIM11 negatively regulates IFNβ production and antiviral activity by targeting TBK1. Lee Y, et al. PLoS One, 2013. PMID 23675467, Free PMC Article
    5. Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Tuoc TC, et al. Genes Dev, 2008 Jul 15. PMID 18628401, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
      Title: TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
    2. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
      Title: TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy.
    3. The results suggest that TRIM11 plays a role in the regulation of intracellular humanin level through ubiquitin-mediated protein degradation pathways.
      Title: A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of AIM2 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in suppression of viral release by host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM11
    Names
    RING-type E3 ubiquitin transferase TRIM11
    tripartite motif-containing protein 11
    NP_001277917.1
    NP_444398.1
    XP_006534642.1
    XP_011247637.1
    XP_030102306.1
    XP_036013004.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290988.1 → NP_001277917.1  E3 ubiquitin-protein ligase TRIM11 isoform 1

      See identical proteins and their annotated locations for NP_001277917.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK040618, AK139477, AL662809
      Consensus CDS
      CCDS70195.1
      UniProtKB/Swiss-Prot
      Q99PQ2
      Related
      ENSMUSP00000104438.4, ENSMUST00000108810.10
      Conserved Domains (3) summary
      pfam00643
      Location:87 → 127
      zf-B_box; B-box zinc finger
      pfam15227
      Location:16 → 56
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cl02614
      Location:303 → 471
      SPRY; SPRY domain

    2. NM_053168.2 → NP_444398.1  E3 ubiquitin-protein ligase TRIM11 isoform 2

      See identical proteins and their annotated locations for NP_444398.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK040618, AK139477, AL662809
      Consensus CDS
      CCDS36168.1
      UniProtKB/Swiss-Prot
      A2A868, A2AB84, Q3TCL5, Q8VDX5, Q99PQ2
      Related
      ENSMUSP00000090749.7, ENSMUST00000093061.7
      Conserved Domains (3) summary
      pfam00643
      Location:87 → 127
      zf-B_box; B-box zinc finger
      pfam15227
      Location:16 → 56
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cl02614
      Location:287 → 455
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58865054..58882288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157111.1 → XP_036013004.1  E3 ubiquitin-protein ligase TRIM11 isoform X1

      Conserved Domains (4) summary
      COG1196
      Location:132 → 234
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00162
      Location:16 → 56
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:90 → 131
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:13 → 57
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_006534579.4 → XP_006534642.1  E3 ubiquitin-protein ligase TRIM11 isoform X3

      UniProtKB/TrEMBL
      A2AB83
      Conserved Domains (4) summary
      COG1196
      Location:132 → 234
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00162
      Location:16 → 56
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:90 → 131
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:13 → 57
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_030246446.2 → XP_030102306.1  E3 ubiquitin-protein ligase TRIM11 isoform X2

      Conserved Domains (1) summary
      cl02614
      Location:135 → 303
      SPRY; SPRY domain

    4. XM_011249335.4 → XP_011247637.1  E3 ubiquitin-protein ligase TRIM11 isoform X4

      Conserved Domains (1) summary
      cl02614
      Location:62 → 230
      SPRY; SPRY domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PQ2.1 GenPept UniProtKB/Swiss-Prot:Q99PQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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