polr1b RNA polymerase I subunit B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: polr1bprovided by ZNC
Official Full Name: RNA polymerase I subunit Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1598
See related: Ensembl:ENSDARG00000077469 AllianceGenome:ZFIN:ZDB-GENE-040426-1598
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66298; wu:fc91a05
Summary: Enables RNA polymerase I activity. Involved in neural crest cell migration. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including alar plate midbrain region; eye; liver; musculature system; and optic tectum. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Orthologous to human POLR1B (RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (41917625..41940467)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (41791655..41814497)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi06d10.x1 (e-PCR)
- UniSTS:196702

fc91a05.x1 (e-PCR)
- UniSTS:188385

Clone Names

MGC66298, MGC113960, MGC158198, MGC192771

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA-directed 5'-3' RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase I activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase I subunit RPA2

Names: RNA polymerase I polypeptide B; RNA polymerase I subunit 2; polymerase (RNA) I polypeptide B

NP_956812.2

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200518.2 → NP_956812.2 DNA-directed RNA polymerase I subunit RPA2

See identical proteins and their annotated locations for NP_956812.2

Status: PROVISIONAL

Source sequence(s)

BC097040

UniProtKB/Swiss-Prot

B8JKD7

UniProtKB/TrEMBL

Q4V967

Related

ENSDARP00000100185.3, ENSDART00000114741.5

Conserved Domains (3) summary

COG0085
Location:16 → 1132

RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]

cd00653
Location:37 → 1130

RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...

pfam06883
Location:561 → 614

RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain