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    Myom3 myomesin family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 242702, updated on 9-May-2024

    Summary

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    Official Symbol
    Myom3provided by MGI
    Official Full Name
    myomesin family, member 3provided by MGI
    Primary source
    MGI:MGI:2685280
    See related
    Ensembl:ENSMUSG00000037139 AllianceGenome:MGI:2685280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm434; 8430427K15Rik
    Summary
    Enables protein homodimerization activity. Predicted to be involved in muscle contraction. Located in M band. Is expressed in diaphragm; leg; skeletal musculature; and somite. Orthologous to human MYOM3 (myomesin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 2.0), placenta adult (RPKM 0.8) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myom3 in Genome Data Viewer
    Location:
    4 D3; 4 68.0 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135486688..135542882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135758800..135815571)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene interleukin 22 receptor, alpha 1 Neighboring gene S-phase kinase-associated protein 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_11736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135411492-135411675 Neighboring gene STARR-positive B cell enhancer ABC_E7999 Neighboring gene serine and arginine-rich splicing factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E4683 Neighboring gene proline-rich nuclear receptor coactivator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments. du Puy L, et al. Int J Dev Biol, 2012. PMID 22562206
    2. Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies. Rouillon J, et al. Hum Mol Genet, 2015 Sep 1. PMID 26060189, Free PMC Article
    3. Myomesin 3, a novel structural component of the M-band in striated muscle. Schoenauer R, et al. J Mol Biol, 2008 Feb 15. PMID 18177667
    4. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. Beqqali A, et al. J Cell Sci, 2010 Apr 1. PMID 20215401
    5. The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Gómez-Del Arco P, et al. Cell Metab, 2016 May 10. PMID 27166947

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYOM3 fragments hold promise for minimally invasive assessment of experimental therapies for DMD and other neuromuscular disorders.
      Title: Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies.
    2. Myomesin 3, a novel structural component of the M-band in striated muscle.
      Title: Myomesin 3, a novel structural component of the M-band in striated muscle.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myomesin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085509.2 → NP_001078978.1  myomesin-3

      See identical proteins and their annotated locations for NP_001078978.1

      Status: VALIDATED

      Source sequence(s)
      AL662911
      Consensus CDS
      CCDS38921.1
      UniProtKB/Swiss-Prot
      A2ABU4
      Related
      ENSMUSP00000101480.2, ENSMUST00000105854.2
      Conserved Domains (5) summary
      cd00096
      Location:171 → 244
      Ig; Immunoglobulin domain
      smart00410
      Location:1137 → 1207
      IG_like; Immunoglobulin like
      cd00063
      Location:804 → 893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:1343 → 1426
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:1336 → 1426
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135486688..135542882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320223.3 → XP_017175712.1  myomesin-3 isoform X1

      Conserved Domains (3) summary
      cd00063
      Location:804 → 893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:154 → 247
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:272 → 363
      Ig; Immunoglobulin domain

    2. XM_017320224.2 → XP_017175713.1  myomesin-3 isoform X2

      Conserved Domains (3) summary
      cd00063
      Location:221 → 310
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:555 → 619
      Ig; Immunoglobulin domain
      cl11960
      Location:753 → 843
      Ig; Immunoglobulin domain

    RNA

    1. XR_003954947.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ABU4.1 GenPept UniProtKB/Swiss-Prot:A2ABU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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