Dspp dentin sialophosphoprotein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dsppprovided by MGI
Official Full Name: dentin sialophosphoproteinprovided by MGI
Primary source: MGI:MGI:109172
See related: Ensembl:ENSMUSG00000053268 AllianceGenome:MGI:109172
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dpp; Dsp; Dmp2; Dmp3
Summary: This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mice lacking the encoded protein exhibit hypomineralization defects in dentin, similar to human dentinogenesis imperfecta. [provided by RefSeq, Feb 2016]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 50.59 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (104318569..104327993)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (104170703..104180127)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dentin defects caused by a Dspp[-1] frameshift mutation are associated with the activation of autophagy.
Title: Dentin defects caused by a Dspp(-1) frameshift mutation are associated with the activation of autophagy.
Mouse Dspp frameshift model of human dentinogenesis imperfecta.
Title: Mouse Dspp frameshift model of human dentinogenesis imperfecta.
DPP promotes odontogenic differentiation of DPSCs through NF-kappaB signaling.
Title: DPP promotes odontogenic differentiation of DPSCs through NF-κB signaling.
DSPP dosage affects tooth development and dentin mineralization.
Title: DSPP dosage affects tooth development and dentin mineralization.
Dentin Sialophosphoprotein Deletion Leads to Femoral Head Cartilage Attenuation and Subchondral Bone Ill-mineralization.
Title: Dentin Sialophosphoprotein Deletion Leads to Femoral Head Cartilage Attenuation and Subchondral Bone Ill-mineralization.
a mutation in Dspp causes dentinogenesis imperfecta
Title: Mutant Dentin Sialophosphoprotein Causes Dentinogenesis Imperfecta.
epithelial Wnt/beta-catenin signaling is capable of inducing Dspp expression in non-dental mesenchyme
Title: Persistent Wnt/β-catenin signaling in mouse epithelium induces the ectopic Dspp expression in cheek mesenchyme.
novel regulatory mechanism by which Cbfalpha1 transcriptionally enhances DSPP expression
Title: Cbfα1 hinders autophagy by DSPP upregulation in odontoblast differentiation.
Gene vps4b plays a significant role in the development of tooth germ. The expression of DSPP and COL- may be controlled by gene vps4b and regulates the development of tooth dentin and cementum together with vps4b.
Title: [Spatio-temporal expression of dentin sialophosphoprotein and collagen Ⅰ during molar tooth germ development in vps4b knockout mouse].
our findings demonstrate that MMP9 is important for tooth development and DSP is a novel target of MMP9 during dentinogenesis.
Title: Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548471

NoName (e-PCR)
- UniSTS:489125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within S-shaped body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ameloblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within amelogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within connective tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dentinogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dentinogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression involved in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mandibular condyle articular cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal to epithelial transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of growth plate cartilage chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within odontoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of enamel mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of odontoblast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: dentin sialophosphoprotein

Names: DMP-3; dentin matrix protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010080.3 → NP_034210.2 dentin sialophosphoprotein preproprotein

Status: REVIEWED

Source sequence(s)

AC164587, BC116173

Consensus CDS

CCDS39190.1

UniProtKB/TrEMBL

E9Q9Z9

Related

ENSMUSP00000108391.2, ENSMUST00000112771.2

Conserved Domains (2) summary

TIGR00927
Location:126 → 367

2A1904; K+-dependent Na+/Ca+ exchanger

pfam09507
Location:326 → 476

CDC27; DNA polymerase subunit Cdc27