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    Wbp11 WW domain binding protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 60321, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wbp11provided by MGI
    Official Full Name
    WW domain binding protein 11provided by MGI
    Primary source
    MGI:MGI:1891823
    See related
    Ensembl:ENSMUSG00000030216 AllianceGenome:MGI:1891823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npwbp; SIPP1; D6Wsu113e; 2510026P17Rik
    Summary
    Enables protein phosphatase regulator activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nuclear speck. Is expressed in several structures, including blood; embryo ectoderm; embryo mesenchyme; extraembryonic component; and heart. Orthologous to human WBP11 (WW domain binding protein 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 80.0), CNS E11.5 (RPKM 24.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wbp11 in Genome Data Viewer
    Location:
    6 G1; 6 66.72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136790652..136805214, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136813654..136828216, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17608 Neighboring gene H4 histone 16 Neighboring gene H2J.A histone Neighboring gene STARR-seq mESC enhancer starr_17611 Neighboring gene cDNA sequence BC049715 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene STARR-seq mESC enhancer starr_17612 Neighboring gene ADP-ribosyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice. Martin EMMA, et al. Hum Mol Genet, 2020 Dec 4. PMID 33276377, Free PMC Article
    2. Nucleocytoplasmic shuttling of the splicing factor SIPP1. Llorian M, et al. J Biol Chem, 2005 Nov 18. PMID 16162498
    3. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724750, Free PMC Article
    4. SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Llorian M, et al. Biochem J, 2004 Feb 15. PMID 14640981, Free PMC Article
    5. Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. Shu H, et al. Mol Cell Proteomics, 2004 Mar. PMID 14729942

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of SIPP1 as a pre-mRNA splicing factor and a binding partner of protein phosphatase-1.
      Title: SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.
    2. SIPP1 is a positive regulator of pre-mRNA splicing that is regulated by nucleocytoplasmic shuttling
      Title: Nucleocytoplasmic shuttling of the splicing factor SIPP1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WW domain-binding protein 11
    Names
    Npw38-binding protein
    WBP-11
    splicing factor that interacts with PQBP-1 and PP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021714.4 → NP_068360.4  WW domain-binding protein 11

      See identical proteins and their annotated locations for NP_068360.4

      Status: VALIDATED

      Source sequence(s)
      AC122804, AK041079
      Consensus CDS
      CCDS20655.1
      UniProtKB/Swiss-Prot
      O88539, Q3UMD8, Q8VDI0, Q923D5
      UniProtKB/TrEMBL
      Q3U6Q1
      Related
      ENSMUSP00000112213.2, ENSMUST00000116514.4
      Conserved Domains (1) summary
      pfam09429
      Location:12 → 92
      Wbp11; WW domain binding protein 11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136790652..136805214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321693.1 → XP_017177182.1  WW domain-binding protein 11 isoform X1

      UniProtKB/Swiss-Prot
      O88539, Q3UMD8, Q8VDI0, Q923D5
      UniProtKB/TrEMBL
      Q3U6Q1
      Conserved Domains (1) summary
      pfam09429
      Location:12 → 92
      Wbp11; WW domain binding protein 11

    2. XM_030255522.1 → XP_030111382.1  WW domain-binding protein 11 isoform X1

      UniProtKB/Swiss-Prot
      O88539, Q3UMD8, Q8VDI0, Q923D5
      UniProtKB/TrEMBL
      Q3U6Q1
      Conserved Domains (1) summary
      pfam09429
      Location:12 → 92
      Wbp11; WW domain binding protein 11
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923D5.2 GenPept UniProtKB/Swiss-Prot:Q923D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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