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    Zfp397 zinc finger protein 397 [ Mus musculus (house mouse) ]

    Gene ID: 69256, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp397provided by MGI
    Official Full Name
    zinc finger protein 397provided by MGI
    Primary source
    MGI:MGI:1916506
    See related
    Ensembl:ENSMUSG00000024276 AllianceGenome:MGI:1916506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810411K16Rik; 6720480F11Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to be involved in negative regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytosol; microtubule cytoskeleton; and nucleolus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF397 (zinc finger protein 397). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 10.6), CNS E14 (RPKM 9.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 A2; 18 12.44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (24085798..24098030)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (23952741..23964671)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44048 Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene predicted gene, 46611 Neighboring gene ribosomal protein L19, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_44049 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:24145637-24145876 Neighboring gene STARR-seq mESC enhancer starr_44051 Neighboring gene zinc finger protein 35 Neighboring gene zinc finger protein 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 397

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027007.2 → NP_081283.2  zinc finger protein 397

      See identical proteins and their annotated locations for NP_081283.2

      Status: VALIDATED

      Source sequence(s)
      AC126807, AK032001, AY338468
      Consensus CDS
      CCDS29096.1
      UniProtKB/TrEMBL
      Q7TNK4
      Related
      ENSMUSP00000057253.5, ENSMUST00000060762.6
      Conserved Domains (3) summary
      smart00431
      Location:46 → 152
      SCAN; leucine rich region
      COG5048
      Location:264 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      24085798..24098030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246997.4 → XP_011245299.1  zinc finger protein 397 isoform X1

      See identical proteins and their annotated locations for XP_011245299.1

      UniProtKB/TrEMBL
      Q7TNK4
      Conserved Domains (3) summary
      smart00431
      Location:46 → 152
      SCAN; leucine rich region
      COG5048
      Location:264 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011246996.3 → XP_011245298.1  zinc finger protein 397 isoform X1

      See identical proteins and their annotated locations for XP_011245298.1

      UniProtKB/TrEMBL
      Q7TNK4
      Conserved Domains (3) summary
      smart00431
      Location:46 → 152
      SCAN; leucine rich region
      COG5048
      Location:264 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_180988.1: Suppressed sequence

      Description
      NM_180988.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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