Stard9 StAR related lipid transfer domain containing 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stard9provided by MGI
Official Full Name: StAR related lipid transfer domain containing 9provided by MGI
Primary source: MGI:MGI:3045258
See related: Ensembl:ENSMUSG00000033705 AllianceGenome:MGI:3045258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kif16a; mKIAA1300; 4831403C07Rik; E230025N21Rik
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement and spindle assembly. Predicted to be located in centriole; cytoplasm; and nucleus. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Orthologous to human STARD9 (StAR related lipid transfer domain containing 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 5.2), testis adult (RPKM 4.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.37 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (120459567..120562371)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (120629086..120729033)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival.
Title: StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Dcr30 (e-PCR), detects polymorphism
- UniSTS:142305

D2Dcr32 (e-PCR), detects polymorphism
- UniSTS:142306

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stAR-related lipid transfer protein 9

Names: N-3 kinesin; START domain containing 9; START domain-containing protein 9; kinesin 16A; kinesin family member 16A; kinesin-like protein Kif16a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370940.1 → NP_001357869.1 stAR-related lipid transfer protein 9

Status: VALIDATED

Source sequence(s)

AL772299, AL935168

UniProtKB/Swiss-Prot

O35058, Q80TF6, Q8C121, Q8CFL0

Related

ENSMUSP00000136055.2, ENSMUST00000180041.9

Conserved Domains (4) summary

cd00060
Location:481 → 581

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:2 → 391

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:390 → 504

Kinesin_assoc; Kinesin-associated

cl14643
Location:4381 → 4585

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

120459567..120562371

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162495.1 → XP_036018388.1 stAR-related lipid transfer protein 9 isoform X1

UniProtKB/Swiss-Prot

O35058, Q80TF6, Q8C121, Q8CFL0

Conserved Domains (4) summary

cd00060
Location:481 → 594

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:2 → 391

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam16183
Location:390 → 504

Kinesin_assoc; Kinesin-associated

cl14643
Location:4394 → 4598

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006500511.4 → XP_006500574.1 stAR-related lipid transfer protein 9 isoform X3

UniProtKB/Swiss-Prot

O35058, Q80TF6, Q8C121, Q8CFL0

Conserved Domains (2) summary

cd00060
Location:7 → 87

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl14643
Location:3887 → 4091

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_036162496.1 → XP_036018389.1 stAR-related lipid transfer protein 9 isoform X2

UniProtKB/Swiss-Prot

O35058, Q80TF6, Q8C121, Q8CFL0

Conserved Domains (4) summary

cd00060
Location:125 → 238

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam16183
Location:34 → 148

Kinesin_assoc; Kinesin-associated

cl14643
Location:4038 → 4242

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

cl22853
Location:1 → 35

Motor_domain; Myosin and Kinesin motor domain
XM_006500512.5 → XP_006500575.1 stAR-related lipid transfer protein 9 isoform X5

UniProtKB/Swiss-Prot

O35058, Q80TF6, Q8C121, Q8CFL0

Conserved Domains (2) summary

pfam13868
Location:3536 → 3584

TPH; Trichohyalin-plectin-homology domain

cl14643
Location:3707 → 3911

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_030251969.2 → XP_030107829.1 stAR-related lipid transfer protein 9 isoform X5

UniProtKB/Swiss-Prot

O35058, Q80TF6, Q8C121, Q8CFL0

Conserved Domains (2) summary

pfam13868
Location:3536 → 3584

TPH; Trichohyalin-plectin-homology domain

cl14643
Location:3707 → 3911

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_036162497.1 → XP_036018390.1 stAR-related lipid transfer protein 9 isoform X4

UniProtKB/Swiss-Prot

O35058, Q80TF6, Q8C121, Q8CFL0

Conserved Domains (1) summary

cl14643
Location:3755 → 3959

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RNA

XR_004940707.1 RNA Sequence
XR_004940706.1 RNA Sequence
XR_004940708.1 RNA Sequence

Related

ENSMUST00000140843.9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_010621.1: Suppressed sequence

Description

NM_010621.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.