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    Hr4 Hormone receptor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31162, updated on 10-May-2024

    Summary

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    Official Symbol
    Hr4provided by FlyBase
    Official Full Name
    Hormone receptor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0264562
    Locus tag
    Dmel_CG43934
    See related
    AllianceGenome:FB:FBgn0264562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null
    Old locus tag
    Dmel_CG16902; Dmel_CG3600; Dmel_CG42527
    Summary
    Enables nuclear receptor activity. Involved in several processes, including cellular response to hypoxia; negative regulation of ecdysone receptor-mediated signaling pathway; and regulation of pupariation. Located in cytoplasm and nucleus. Is expressed in border follicle cell; centripetal follicle cell; embryonic/larval fat body; prothoracic gland; and ring gland. Orthologous to human NR6A1 (nuclear receptor subfamily 6 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Hr4 in Genome Data Viewer
    Location:
    2B16-2C1; 1-0.5 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1941940..2007956)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1835973..1901989)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45478 Neighboring gene mir-2496 stem loop Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis. Weaver LN, et al. Development, 2021 Mar 9. PMID 33547134, Free PMC Article
    2. Early-late genes of the ecdysone cascade as models for transcriptional studies. Mazina MY, et al. Cell Cycle, 2015. PMID 26506480, Free PMC Article
    3. The Development of Reporter System for the Investigation of Molecular Mechanisms of Ecdysone Response. Mazina MY, et al. Dokl Biochem Biophys, 2019 Mar. PMID 31201635
    4. Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila. Kachaev ZM, et al. Cell Cycle, 2018. PMID 29995569, Free PMC Article
    5. Genomic mapping of binding regions for the Ecdysone receptor protein complex. Gauhar Z, et al. Genome Res, 2009 Jun. PMID 19237466, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis.
      Title: Hormone receptor 4 is required in muscles and distinct ovarian cell types to regulate specific steps of Drosophila oogenesis.
    2. DHR3 and Hr4 gene expression is dose dependent, is completely controlled by the hormone titer and decreases within hours of 20-hydroxyecdysone withdrawal.
      Title: Early-late genes of the ecdysone cascade as models for transcriptional studies.
    3. Following the onset of zygotic gene expression, Slam and Nullo together stabilise the retracting metaphase furrow and Slam triggers invagination of the cleavage furrow.
      Title: Function and dynamics of slam in furrow formation in early Drosophila embryo.
    4. Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development
      Title: Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development.
    5. Results show that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular differentiation in response to the hormone.
      Title: Genomic mapping of binding regions for the Ecdysone receptor protein complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of negative regulation of ecdysone receptor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pupariation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hormone receptor 4
    Names
    CG43934-PC
    CG43934-PD
    CG43934-PE
    CG43934-PF
    CG43934-PG
    CG43934-PH
    CG43934-PI
    CG43934-PJ
    CG43934-PK
    Hr4-PC
    Hr4-PD
    Hr4-PE
    Hr4-PF
    Hr4-PG
    Hr4-PH
    Hr4-PI
    Hr4-PJ
    Hr4-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1941940..2007956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272234.1 → NP_001259163.1  hormone receptor 4, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA3
      Conserved Domains (2) summary
      cd06953
      Location:1580 → 1839
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1237 → 1326
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    2. NM_001272233.2 → NP_001259162.1  hormone receptor 4, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA3
      Conserved Domains (2) summary
      cd06953
      Location:1580 → 1839
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1237 → 1326
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    3. NM_001272230.1 → NP_001259159.1  hormone receptor 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGH1
      Conserved Domains (2) summary
      cd06953
      Location:1266 → 1525
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:923 → 1012
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    4. NM_001272227.1 → NP_001259156.1  hormone receptor 4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDJ1
      Conserved Domains (2) summary
      cd06953
      Location:1723 → 1982
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1380 → 1469
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    5. NM_001272231.1 → NP_001259160.1  hormone receptor 4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIR5
      Conserved Domains (2) summary
      cd06953
      Location:1256 → 1515
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:913 → 1002
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    6. NM_001272232.1 → NP_001259161.1  hormone receptor 4, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDJ5
      Conserved Domains (2) summary
      cd06953
      Location:1256 → 1515
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:913 → 1002
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    7. NM_001038734.2 → NP_001033823.1  hormone receptor 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96836, Q56AW0, Q9W539
      Conserved Domains (2) summary
      cd06953
      Location:1256 → 1514
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:913 → 1002
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    8. NM_001272229.1 → NP_001259158.1  hormone receptor 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGQ8
      Conserved Domains (2) summary
      cd06953
      Location:1580 → 1838
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1237 → 1326
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers

    9. NM_001272228.1 → NP_001259157.1  hormone receptor 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA1
      Conserved Domains (2) summary
      cd06953
      Location:1349 → 1607
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1006 → 1095
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDJ1 M9PDJ1
    M9PDJ5 M9PDJ5
    M9PGA1 M9PGA1
    M9PGA3 M9PGA3
    M9PGH1 M9PGH1
    M9PGQ8 M9PGQ8
    M9PIR5 M9PIR5
    O96835 O96835
    Q9W539.4 Q9W539

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