U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ppk7 pickpocket 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33886, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ppk7provided by FlyBase
    Official Full Name
    pickpocket 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0031802
    Locus tag
    Dmel_CG9499
    See related
    AllianceGenome:FB:FBgn0031802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9499; Dmel\CG9499; Ppk7; PPK7
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in embryonic/larval dorsal branch; embryonic/larval dorsal trunk; embryonic/larval transverse connective; and tracheal tip cell. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC4 (acid sensing ion channel subunit family member 4); and ASIC5 (acid sensing ion channel subunit family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ppk7 in Genome Data Viewer
    Location:
    26C3-26C3; 2-19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6352324..6354331, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6352324..6354331, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pickpocket 14 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster. Harrison BR, et al. BMC Genomics, 2020 May 4. PMID 32366330, Free PMC Article
    2. Evolution of the Insect PPK Gene Family. Latorre-Estivalis JM, et al. Genome Biol Evol, 2021 Sep 1. PMID 34390578, Free PMC Article
    3. Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Liu L, et al. Proc Natl Acad Sci U S A, 2003 Feb 18. PMID 12571352, Free PMC Article
    4. Contribution of Drosophila DEG/ENaC genes to salt taste. Liu L, et al. Neuron, 2003 Jul 3. PMID 12848938
    5. ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. Lu B, et al. PLoS Genet, 2012. PMID 22438833, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pickpocket 7
    Names
    CG9499-PA
    ppk7-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6352324..6354331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135172.2 → NP_609016.2  pickpocket 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609016.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86LH2, Q9VME9
      Conserved Domains (1) summary
      pfam00858
      Location:38 → 493
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VME9 Q9VME9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Tools
    Miscellaneous