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    Tsp42Er Tetraspanin 42Er [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35629, updated on 10-May-2024

    Summary

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    Official Symbol
    Tsp42Erprovided by FlyBase
    Official Full Name
    Tetraspanin 42Erprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033139
    Locus tag
    Dmel_CG12837
    See related
    AllianceGenome:FB:FBgn0033139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12837; Dm.Tsp42Er; Dmel\CG12837
    Summary
    Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human TSPAN3 (tetraspanin 3) and TSPAN8 (tetraspanin 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Tsp42Er in Genome Data Viewer
    Location:
    42E7-42E7; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7064399..7066113)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2951904..2953618)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 3 Neighboring gene Tetraspanin 42Eq Neighboring gene transfer RNA:Threonine-AGT 2-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    2. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
    3. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article
    4. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article
    5. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 42Er
    Names
    CG12837-PA
    Tsp42Er-PA
    tetraspanin 42E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7064399..7066113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078920.3 → NP_523644.1  tetraspanin 42Er [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHL8, Q1EC46
      Conserved Domains (2) summary
      cd03127
      Location:93 → 174
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 195
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1EC46 Q1EC46

    Gene LinkOut

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