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    CG1317 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38300, updated on 10-May-2024

    Summary

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    Official Symbol
    CG1317provided by FlyBase
    Primary source
    FLYBASE:FBgn0035333
    Locus tag
    Dmel_CG1317
    See related
    AllianceGenome:FB:FBgn0035333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1317; Teb4
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent ERAD pathway. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG1317 in Genome Data Viewer
    Location:
    62D7-62D7; 3-2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2367843..2371939, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2367843..2371939, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Myosuppressin receptor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination. Zhang Y, et al. Mol Cell, 2022 Apr 21. PMID 35245436
    2. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. Fattouh N, et al. PLoS Negl Trop Dis, 2019 Mar. PMID 30893296, Free PMC Article
    3. NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways. Sheng Z, et al. PLoS Genet, 2020 Jun. PMID 32559195, Free PMC Article
    4. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
    5. Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Krauchunas AR, et al. Dev Biol, 2012 Oct 1. PMID 22884528, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1317-PB
    CG1317-PC
    CG1317-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2367843..2371939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299984.1 → NP_001286913.1  uncharacterized protein Dmel_CG1317, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWJ1, Q9W023
      Conserved Domains (2) summary
      smart00744
      Location:9 → 56
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
      TIGR04346
      Location:737 → 913
      DotA_TraY; conjugal transfer/type IV secretion protein DotA/TraY

    2. NM_001169857.2 → NP_001163328.1  uncharacterized protein Dmel_CG1317, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWJ1, Q9W023
      Conserved Domains (2) summary
      smart00744
      Location:9 → 56
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
      TIGR04346
      Location:737 → 913
      DotA_TraY; conjugal transfer/type IV secretion protein DotA/TraY

    3. NM_139458.4 → NP_647715.2  uncharacterized protein Dmel_CG1317, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647715.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWJ1, Q9W023
      Related
      FBpp0072779
      Conserved Domains (2) summary
      smart00744
      Location:9 → 56
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
      TIGR04346
      Location:737 → 913
      DotA_TraY; conjugal transfer/type IV secretion protein DotA/TraY
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AWJ1 Q6AWJ1
    Q95TW3 Q95TW3
    Q9W023 Q9W023

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