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    grb2b growth factor receptor-bound protein 2b [ Danio rerio (zebrafish) ]

    Gene ID: 406308, updated on 1-Jun-2024

    Summary

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    Official Symbol
    grb2bprovided by ZNC
    Official Full Name
    growth factor receptor-bound protein 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1975
    See related
    Ensembl:ENSDARG00000038059 AllianceGenome:ZFIN:ZDB-GENE-040426-1975
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    grb2; fb18e12; zgc:73077; wu:fb18e12; wu:fb34e06
    Summary
    Predicted to be located in Golgi apparatus; endosome; and nucleus. Is expressed in central nervous system and trigeminal placode. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See grb2b in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25435816..25492374, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (25306051..25361832, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene bromodomain PHD finger transcription factor Neighboring gene transfer RNA serine (anticodon AGA) Neighboring gene melanin-concentrating hormone receptor 1b Neighboring gene ubiquitin specific peptidase 43b Neighboring gene uncharacterized LOC101886214

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cautious use of fli1a:EGFP transgenic zebrafish in vascular research. Liu Z, et al. Biochem Biophys Res Commun, 2012 Oct 12. PMID 22995292
    2. The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk. Mauri C, et al. Angiogenesis, 2021 May. PMID 33677657, Free PMC Article
    3. Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. Herrero-Turrión MJ, et al. BMC Genomics, 2014 Oct 8. PMID 25294025, Free PMC Article
    4. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
    5. RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. Saddala MS, et al. BMC Genomics, 2020 Feb 7. PMID 32033529, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk.
      Title: The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    growth factor receptor-bound protein 2; growth factor receptor-bound protein 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213035.1 → NP_998200.1  growth factor receptor-bound protein 2b

      See identical proteins and their annotated locations for NP_998200.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059450
      UniProtKB/TrEMBL
      A0A8M1PEH0, Q6PC73
      Related
      ENSDARP00000146459.1, ENSDART00000184651.1
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      25435816..25492374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171575.4 → XP_005171632.1  growth factor receptor-bound protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005171632.1

      UniProtKB/TrEMBL
      A0A8M1PEH0, Q6PC73
      Related
      ENSDARP00000055472.3, ENSDART00000055473.6
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    2. XM_009299360.3 → XP_009297635.1  growth factor receptor-bound protein 2 isoform X1

      See identical proteins and their annotated locations for XP_009297635.1

      UniProtKB/TrEMBL
      A0A8M1PEH0, Q6PC73
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    3. XM_005171574.4 → XP_005171631.1  growth factor receptor-bound protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005171631.1

      UniProtKB/TrEMBL
      A0A8M1PEH0, Q6PC73
      Related
      ENSDARP00000122829.1, ENSDART00000147322.3
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    4. XM_017353773.2 → XP_017209262.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M1PEH0, Q6PC73
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    5. XM_017353775.2 → XP_017209264.1  growth factor receptor-bound protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M1PEH0, Q6PC73
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:1 → 56
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160 → 212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    Nucleotide Protein Strain
    Heading Accession and Version

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