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    Zfand2b zinc finger, AN1 type domain 2B [ Mus musculus (house mouse) ]

    Gene ID: 68818, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfand2bprovided by MGI
    Official Full Name
    zinc finger, AN1 type domain 2Bprovided by MGI
    Primary source
    MGI:MGI:1916068
    See related
    Ensembl:ENSMUSG00000026197 AllianceGenome:MGI:1916068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110060O18Rik
    Summary
    Enables K48-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein targeting to ER; and regulation of insulin-like growth factor receptor signaling pathway. Located in endoplasmic reticulum. Is anchored component of membrane. Part of proteasome complex. Orthologous to human ZFAND2B (zinc finger AN1-type containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 27.4), large intestine adult (RPKM 24.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfand2b in Genome Data Viewer
    Location:
    1 C4; 1 38.61 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75145290..75148270)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75168646..75171626)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cyclin Pas1/PHO80 domain containing 1 Neighboring gene reticulophagy regulator family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1550 Neighboring gene ATP-binding cassette, sub-family B member 6 Neighboring gene STARR-positive B cell enhancer ABC_E8982 Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains. Rahighi S, et al. Structure, 2016 Mar 1. PMID 26876100, Free PMC Article
    2. Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. Glinka T, et al. Biochem J, 2014 Jan 15. PMID 24160817
    3. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. Yun C, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18467495, Free PMC Article
    4. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Osorio FG, et al. Nat Med, 2016 Jan. PMID 26692333
    5. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K48-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of insulin-like growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AN1-type zinc finger protein 2B
    Names
    AIRAP-like protein
    arsenite-inducible RNA-associated protein-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159905.1 → NP_001153377.1  AN1-type zinc finger protein 2B

      See identical proteins and their annotated locations for NP_001153377.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three transcripts encode the same protein.
      Source sequence(s)
      AK151430, BX633014, CX217579
      Consensus CDS
      CCDS15064.1
      UniProtKB/Swiss-Prot
      Q91X58, Q9D0W4
      UniProtKB/TrEMBL
      E0CY18
      Related
      ENSMUSP00000125086.2, ENSMUST00000160439.8
      Conserved Domains (2) summary
      pfam01428
      Location:100 → 136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:197 → 213
      UIM; Ubiquitin interaction motif

    2. NM_001159906.1 → NP_001153378.1  AN1-type zinc finger protein 2B

      See identical proteins and their annotated locations for NP_001153378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three transcripts encode the same protein.
      Source sequence(s)
      AK151430, BX633014, BY197482
      Consensus CDS
      CCDS15064.1
      UniProtKB/Swiss-Prot
      Q91X58, Q9D0W4
      UniProtKB/TrEMBL
      E0CY18
      Related
      ENSMUSP00000124552.2, ENSMUST00000162768.8
      Conserved Domains (2) summary
      pfam01428
      Location:100 → 136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:197 → 213
      UIM; Ubiquitin interaction motif

    3. NM_026846.3 → NP_081122.2  AN1-type zinc finger protein 2B

      See identical proteins and their annotated locations for NP_081122.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three transcripts encode the same protein.
      Source sequence(s)
      AK151430, BX633014
      Consensus CDS
      CCDS15064.1
      UniProtKB/Swiss-Prot
      Q91X58, Q9D0W4
      UniProtKB/TrEMBL
      E0CY18
      Related
      ENSMUSP00000027394.6, ENSMUST00000027394.12
      Conserved Domains (2) summary
      pfam01428
      Location:100 → 136
      zf-AN1; AN1-like Zinc finger
      pfam02809
      Location:197 → 213
      UIM; Ubiquitin interaction motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75145290..75148270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91X58.1 GenPept UniProtKB/Swiss-Prot:Q91X58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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