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    Frmd3 FERM domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 242506, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Frmd3provided by MGI
    Official Full Name
    FERM domain containing 3provided by MGI
    Primary source
    MGI:MGI:2442466
    See related
    Ensembl:ENSMUSG00000049122 AllianceGenome:MGI:2442466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4.1O; P410; EPB41L4O; 9430066I12Rik
    Summary
    Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoskeleton. Orthologous to human FRMD3 (FERM domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 3.9), whole brain E14.5 (RPKM 2.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C3; 4 36.06 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (73931454..74120451)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (74013228..74202214)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310002L09 gene Neighboring gene Myb/SANT DNA binding domain containing 5 family member 9 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_10543 Neighboring gene STARR-seq mESC enhancer starr_10544 Neighboring gene zinc finger protein 384 pseudogene Neighboring gene lysine (K)-specific demethylase 4C Neighboring gene STARR-positive B cell enhancer mm9_chr4:73965324-73965624

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163732.1 → NP_001157204.1  FERM domain-containing protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different exon for its 3' terminus, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK034956, AK079349
      Consensus CDS
      CCDS51212.1
      UniProtKB/Swiss-Prot
      Q8BHD4
      UniProtKB/TrEMBL
      Q8BV94
      Related
      ENSMUSP00000095615.3, ENSMUST00000098006.9
      Conserved Domains (5) summary
      smart00295
      Location:33 → 225
      B41; Band 4.1 homologues
      pfam00373
      Location:117 → 225
      FERM_M; FERM central domain
      pfam08736
      Location:323 → 357
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 99
      FERM_N; FERM N-terminal domain
      cl17171
      Location:206 → 309
      PH-like; Pleckstrin homology-like domain

    2. NM_172869.5 → NP_766457.1  FERM domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_766457.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL844607, BX088570, BX957282
      Consensus CDS
      CCDS38789.1
      UniProtKB/Swiss-Prot
      A2BEJ6, Q3UF23, Q5SPU0, Q5SPU1, Q8BHD4, Q8C045
      Related
      ENSMUSP00000081514.6, ENSMUST00000084474.6
      Conserved Domains (5) summary
      smart00295
      Location:33 → 225
      B41; Band 4.1 homologues
      pfam00373
      Location:117 → 225
      FERM_M; FERM central domain
      pfam08736
      Location:323 → 357
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 99
      FERM_N; FERM N-terminal domain
      cl17171
      Location:206 → 309
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      73931454..74120451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253548.2 → XP_030109408.1  FERM domain-containing protein 3 isoform X1

      Conserved Domains (2) summary
      pfam08736
      Location:74 → 119
      FA; FERM adjacent (FA)
      cl17171
      Location:11 → 60
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHD4.1 GenPept UniProtKB/Swiss-Prot:Q8BHD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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