Otud7b OTU domain containing 7B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Otud7bprovided by MGI
Official Full Name: OTU domain containing 7Bprovided by MGI
Primary source: MGI:MGI:2654703
See related: Ensembl:ENSMUSG00000038495 AllianceGenome:MGI:2654703
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Za20d1; CEZANNE; Trabid2; 2900060B22Rik; 4930463P07Rik
Summary: Enables K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of transcription by RNA polymerase II; and protein K48-linked deubiquitination. Acts upstream of or within in utero embryonic development and protein deubiquitination. Located in cytoplasm. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 8.7), lung adult (RPKM 6.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 41.65 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (96011759..96068446)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (96104504..96161129)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Kruppel-Like Factor 4.
Title: Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel-Like Factor 4.
The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
Title: The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.
Cezanne is a critical regulator of pathological arterial remodelling by targeting beta-catenin signalling.
Title: Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling.
OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.
Title: OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.
Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-kappaB Signaling Pathway by Targeting OTUD7B.
Title: Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-κB Signaling Pathway by Targeting OTUD7B.
The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20.
Title: The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20.
Cezanne may be a novel antioncogene that has a pivotal role in the invasion of hepatocellular carcinoma.
Title: Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
Title: TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
These findings establish Otud7b as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function.
Title: Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
Title: Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234762

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI462125 (e-PCR)
- UniSTS:178870

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K11-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: OTU domain-containing protein 7B

Names: TRAF binding domain containing 2; cellular zinc finger anti-NF-kappa-B protein; zinc finger A20 domain-containing protein 1; zinc finger protein Cezanne; zinc finger, A20 domain containing 1

NP_001020784.1

EC 3.4.19.12

NP_001020785.1

EC 3.4.19.12

XP_006501448.1

EC 3.4.19.12

XP_006501449.1

EC 3.4.19.12

XP_006501452.1

EC 3.4.19.12

XP_017175035.1

EC 3.4.19.12

XP_017175037.1

EC 3.4.19.12

XP_030108444.1

EC 3.4.19.12

XP_030108445.1

EC 3.4.19.12

XP_036018961.1

EC 3.4.19.12

XP_036018962.1

EC 3.4.19.12

XP_036018963.1

EC 3.4.19.12

XP_036018964.1

EC 3.4.19.12

XP_036018965.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025613.1 → NP_001020784.1 OTU domain-containing protein 7B

See identical proteins and their annotated locations for NP_001020784.1

Status: VALIDATED

Source sequence(s)

AC092094, AK044701, BB596613

Consensus CDS

CCDS17629.1

UniProtKB/Swiss-Prot

B2RUR8, Q8CFS0

Related

ENSMUSP00000088291.3, ENSMUST00000090785.9

Conserved Domains (3) summary

cd14347
Location:4 → 46

UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

pfam01754
Location:798 → 820

zf-A20; A20-like zinc finger

cl19932
Location:189 → 359

OTU; OTU-like cysteine protease
NM_001025614.1 → NP_001020785.1 OTU domain-containing protein 7B

See identical proteins and their annotated locations for NP_001020785.1

Status: VALIDATED

Source sequence(s)

AC092094, AK044701, BB596613

Consensus CDS

CCDS17629.1

UniProtKB/Swiss-Prot

B2RUR8, Q8CFS0

Related

ENSMUSP00000046413.6, ENSMUST00000035519.12

Conserved Domains (3) summary

cd14347
Location:4 → 46

UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

pfam01754
Location:798 → 820

zf-A20; A20-like zinc finger

cl19932
Location:189 → 359

OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

96011759..96068446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252585.2 → XP_030108445.1 OTU domain-containing protein 7B isoform X2

Conserved Domains (2) summary

pfam01754
Location:706 → 728

zf-A20; A20-like zinc finger

cl19932
Location:97 → 267

OTU; OTU-like cysteine protease
XM_036163070.1 → XP_036018963.1 OTU domain-containing protein 7B isoform X1

UniProtKB/Swiss-Prot

B2RUR8, Q8CFS0

Conserved Domains (3) summary

cd14347
Location:4 → 46

UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

pfam01754
Location:798 → 820

zf-A20; A20-like zinc finger

cl19932
Location:189 → 359

OTU; OTU-like cysteine protease
XM_030252584.2 → XP_030108444.1 OTU domain-containing protein 7B isoform X2

Conserved Domains (2) summary

pfam01754
Location:706 → 728

zf-A20; A20-like zinc finger

cl19932
Location:97 → 267

OTU; OTU-like cysteine protease
XM_017319548.3 → XP_017175037.1 OTU domain-containing protein 7B isoform X2

Conserved Domains (2) summary

pfam01754
Location:706 → 728

zf-A20; A20-like zinc finger

cl19932
Location:97 → 267

OTU; OTU-like cysteine protease
XM_036163068.1 → XP_036018961.1 OTU domain-containing protein 7B isoform X1

UniProtKB/Swiss-Prot

B2RUR8, Q8CFS0

Conserved Domains (3) summary

cd14347
Location:4 → 46

UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

pfam01754
Location:798 → 820

zf-A20; A20-like zinc finger

cl19932
Location:189 → 359

OTU; OTU-like cysteine protease
XM_006501385.4 → XP_006501448.1 OTU domain-containing protein 7B isoform X1

See identical proteins and their annotated locations for XP_006501448.1

UniProtKB/Swiss-Prot

B2RUR8, Q8CFS0

Conserved Domains (3) summary

cd14347
Location:4 → 46

UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

pfam01754
Location:798 → 820

zf-A20; A20-like zinc finger

cl19932
Location:189 → 359

OTU; OTU-like cysteine protease
XM_036163069.1 → XP_036018962.1 OTU domain-containing protein 7B isoform X2

Conserved Domains (2) summary

pfam01754
Location:706 → 728

zf-A20; A20-like zinc finger

cl19932
Location:97 → 267

OTU; OTU-like cysteine protease
XM_006501389.4 → XP_006501452.1 OTU domain-containing protein 7B isoform X1

See identical proteins and their annotated locations for XP_006501452.1

UniProtKB/Swiss-Prot

B2RUR8, Q8CFS0

Conserved Domains (3) summary

cd14347
Location:4 → 46

UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

pfam01754
Location:798 → 820

zf-A20; A20-like zinc finger

cl19932
Location:189 → 359

OTU; OTU-like cysteine protease
XM_006501386.3 → XP_006501449.1 OTU domain-containing protein 7B isoform X1

See identical proteins and their annotated locations for XP_006501449.1

UniProtKB/Swiss-Prot

B2RUR8, Q8CFS0

Related

ENSMUSP00000096449.3, ENSMUST00000098849.3

Conserved Domains (3) summary

cd14347
Location:4 → 46

UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

pfam01754
Location:798 → 820

zf-A20; A20-like zinc finger

cl19932
Location:189 → 359

OTU; OTU-like cysteine protease
XM_036163071.1 → XP_036018964.1 OTU domain-containing protein 7B isoform X2

Conserved Domains (2) summary

pfam01754
Location:706 → 728

zf-A20; A20-like zinc finger

cl19932
Location:97 → 267

OTU; OTU-like cysteine protease
XM_036163072.1 → XP_036018965.1 OTU domain-containing protein 7B isoform X2

Conserved Domains (2) summary

pfam01754
Location:706 → 728

zf-A20; A20-like zinc finger

cl19932
Location:97 → 267

OTU; OTU-like cysteine protease
XM_017319546.1 → XP_017175035.1 OTU domain-containing protein 7B isoform X1

UniProtKB/Swiss-Prot

B2RUR8, Q8CFS0

Conserved Domains (3) summary

cd14347
Location:4 → 46

UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins

pfam01754
Location:798 → 820

zf-A20; A20-like zinc finger

cl19932
Location:189 → 359

OTU; OTU-like cysteine protease