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    Epn3 epsin 3 [ Mus musculus (house mouse) ]

    Gene ID: 71889, updated on 12-May-2024

    Summary

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    Official Symbol
    Epn3provided by MGI
    Official Full Name
    epsin 3provided by MGI
    Primary source
    MGI:MGI:1919139
    See related
    Ensembl:ENSMUSG00000010080 AllianceGenome:MGI:1919139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310022G12Rik
    Summary
    Enables EH domain binding activity. Predicted to be involved in endocytosis. Located in clathrin-coated pit. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and respiratory system. Orthologous to human EPN3 (epsin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 51.8), lung adult (RPKM 22.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Epn3 in Genome Data Viewer
    Location:
    11 D; 11 58.9 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94380425..94390800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94489599..94499974, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, T type, alpha 1G subunit Neighboring gene predicted gene, 51872 Neighboring gene STARR-seq mESC enhancer starr_30468 Neighboring gene STARR-positive B cell enhancer ABC_E10707 Neighboring gene spermatogenesis associated 20 Neighboring gene predicted gene, 51873 Neighboring gene MYCBP associated protein Neighboring gene predicted gene, 35650 Neighboring gene radical S-adenosyl methionine domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis. Mori J, et al. Neoplasia, 2017 Mar. PMID 28152424, Free PMC Article
    2. Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. Messa M, et al. Elife, 2014 Aug 13. PMID 25122462, Free PMC Article
    3. Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi. Ko G, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21115825, Free PMC Article
    4. T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. Mohan RA, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32675240, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
      Title: Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
    2. data suggest that epsin 3 cooperates with other bilayer binding proteins with curvature sensing/generating properties in the specialized traffic and membrane remodeling processes typical of gastric parietal cells
      Title: Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables EH domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epsin-3
    Names
    EPS-15-interacting protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361558.1 → NP_001348487.1  epsin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL645809
      UniProtKB/TrEMBL
      Q3TZ84
      Conserved Domains (3) summary
      smart00726
      Location:202 → 221
      UIM; Ubiquitin-interacting motif
      cd03571
      Location:19 → 141
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      cl26464
      Location:275 → 607
      Atrophin-1; Atrophin-1 family

    2. NM_027984.3 → NP_082260.1  epsin-3 isoform 1

      See identical proteins and their annotated locations for NP_082260.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK009469, AL645809
      Consensus CDS
      CCDS25257.1
      UniProtKB/Swiss-Prot
      Q91W69, Q9CV55
      UniProtKB/TrEMBL
      Q3TZ84
      Related
      ENSMUSP00000121390.2, ENSMUST00000127305.2
      Conserved Domains (3) summary
      smart00726
      Location:202 → 221
      UIM; Ubiquitin-interacting motif
      PHA03247
      Location:302 → 634
      PHA03247; large tegument protein UL36; Provisional
      cd16990
      Location:19 → 142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94380425..94390800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534266.4 → XP_006534329.1  epsin-3 isoform X1

      See identical proteins and their annotated locations for XP_006534329.1

      UniProtKB/Swiss-Prot
      Q91W69, Q9CV55
      UniProtKB/TrEMBL
      Q3TZ84
      Conserved Domains (3) summary
      smart00726
      Location:202 → 221
      UIM; Ubiquitin-interacting motif
      PHA03247
      Location:302 → 634
      PHA03247; large tegument protein UL36; Provisional
      cd16990
      Location:19 → 142
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W69.1 GenPept UniProtKB/Swiss-Prot:Q91W69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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