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    Clip3 CAP-GLY domain containing linker protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 76686, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Clip3provided by MGI
    Official Full Name
    CAP-GLY domain containing linker protein 3provided by MGI
    Primary source
    MGI:MGI:1923936
    See related
    Ensembl:ENSMUSG00000013921 AllianceGenome:MGI:1923936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clipr-59; 1500005P14Rik
    Summary
    Predicted to enable ganglioside binding activity and microtubule plus-end binding activity. Involved in positive regulation of glucose transmembrane transport; positive regulation of protein localization to plasma membrane; and positive regulation of protein phosphorylation. Acts upstream of or within fat cell differentiation. Located in plasma membrane and trans-Golgi network. Is expressed in several structures, including central nervous system; genitourinary system; and retina layer. Orthologous to human CLIP3 (CAP-Gly domain containing linker protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 110.2), cortex adult (RPKM 66.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clip3 in Genome Data Viewer
    Location:
    7 B1; 7 17.37 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29991120..30007792)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30291695..30308367)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 62 Neighboring gene ribosomal protein S12, pseudogene 5 Neighboring gene RIKEN cDNA 1700020L13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:31065285-31065586 Neighboring gene THAP domain containing 8, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3711 Neighboring gene alkB homolog 6 Neighboring gene spectrin repeat containing, nuclear envelope family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ClipR-59 interacts with Elmo2 and modulates myoblast fusion. Sun Y, et al. J Biol Chem, 2015 Mar 6. PMID 25572395, Free PMC Article
    2. The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation. Ren W, et al. J Biol Chem, 2012 Aug 3. PMID 22689584, Free PMC Article
    3. DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane. Ren W, et al. Mol Cell Biol, 2013 Nov. PMID 24001771, Free PMC Article
    4. CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Couesnon A, et al. Development, 2013 Apr. PMID 23482493
    5. ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. Ding J, et al. Mol Cell Biol, 2009 Mar. PMID 19139280, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collectively, our studies demonstrate that formation of an Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
      Title: ClipR-59 interacts with Elmo2 and modulates myoblast fusion.
    2. CLIPR-59 is involved in the stabilization of specific motor axons at the neuromuscular junction during mouse late embryogenesis and its role is crucial for mouse perinatal development.
      Title: CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development.
    3. Because ClipR-59 also interacts with Akt and enhances the interaction between Akt and AS160, we suggest that ClipR-59 functions as a scaffold protein to facilitate Akt-mediated AS160 phosphorylation, thereby regulating glucose transport
      Title: The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation.
    4. ClipR-59 functions as a scaffold protein that interacts with phospho-Akt and recruits active Akt on the membrane and may play an important role in adipocyte glucose transport.
      Title: ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ganglioside binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fat cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in membrane biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CAP-Gly domain-containing linker protein 3
    Names
    CLIP-170-related 59 kDa protein
    clip-170 related protein 59 kDa
    cytoplasmic linker protein 170-related 59 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081114.2 → NP_001074583.1  CAP-Gly domain-containing linker protein 3

      See identical proteins and their annotated locations for NP_001074583.1

      Status: VALIDATED

      Source sequence(s)
      AC149067
      Consensus CDS
      CCDS39880.1
      UniProtKB/Swiss-Prot
      B9EHT4, Q7TNI1, Q9DB67
      Related
      ENSMUSP00000014065.9, ENSMUST00000014065.16
      Conserved Domains (3) summary
      sd00045
      Location:120 → 157
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:418 → 482
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:122 → 228
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001360763.1 → NP_001347692.1  CAP-Gly domain-containing linker protein 3

      Status: VALIDATED

      Source sequence(s)
      AC149067
      Consensus CDS
      CCDS39880.1
      UniProtKB/Swiss-Prot
      B9EHT4, Q7TNI1, Q9DB67
      Conserved Domains (3) summary
      sd00045
      Location:120 → 157
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:418 → 482
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:122 → 228
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001360764.1 → NP_001347693.1  CAP-Gly domain-containing linker protein 3

      Status: VALIDATED

      Source sequence(s)
      AC149067
      Consensus CDS
      CCDS39880.1
      UniProtKB/Swiss-Prot
      B9EHT4, Q7TNI1, Q9DB67
      Conserved Domains (3) summary
      sd00045
      Location:120 → 157
      ANK; ANK repeat [structural motif]
      pfam01302
      Location:418 → 482
      CAP_GLY; CAP-Gly domain
      pfam12796
      Location:122 → 228
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29991120..30007792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9EHT4.1 GenPept UniProtKB/Swiss-Prot:B9EHT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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