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    Lypd10 Ly6/PLAUR domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 232972, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Lypd10provided by MGI
    Official Full Name
    Ly6/PLAUR domain containing 10provided by MGI
    Primary source
    MGI:MGI:2681843
    See related
    Ensembl:ENSMUSG00000045587 AllianceGenome:MGI:2681843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium-dependent protein binding activity; integrin binding activity; and protease binding activity. Predicted to be involved in several processes, including neutrophil extravasation; positive regulation of superoxide anion generation; and regulation of vesicle-mediated transport. Predicted to be located in plasma membrane and tertiary granule membrane. Predicted to be active in plasma membrane raft. Predicted to be anchored component of plasma membrane. Is expressed in Meckel's cartilage; bone; and hip. Orthologous to human CD177 (CD177 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 33.0) See more
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    Genomic context

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    Location:
    7 A3; 7 12.38 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24408645..24413960)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24709202..24714535)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1096 Neighboring gene STARR-seq mESC enhancer starr_18275 Neighboring gene predicted gene, 36776 Neighboring gene STARR-seq mESC enhancer starr_18276 Neighboring gene Ly6/PLAUR domain containing 11 Neighboring gene CD177 antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC58740

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neutrophil degranulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ly6/PLAUR domain containing 10; ly6/PLAUR domain containing 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419261.1 → NP_001406190.1  Ly6/PLAUR domain containing 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161488
      UniProtKB/TrEMBL
      Q810N3

    2. NM_001419262.1 → NP_001406191.1  Ly6/PLAUR domain containing 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161488
      UniProtKB/TrEMBL
      Q810N3

    3. NM_001419263.1 → NP_001406192.1  Ly6/PLAUR domain containing 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161488
      UniProtKB/TrEMBL
      Q810N3

    4. NM_001419264.1 → NP_001406193.1  Ly6/PLAUR domain containing 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161488
      UniProtKB/TrEMBL
      Q810N3

    5. NM_199150.2 → NP_954601.1  Ly6/PLAUR domain containing 10 precursor

      See identical proteins and their annotated locations for NP_954601.1

      Status: VALIDATED

      Source sequence(s)
      AC161488
      Consensus CDS
      CCDS20960.1
      UniProtKB/TrEMBL
      Q810N3
      Related
      ENSMUSP00000053275.8, ENSMUST00000051714.9
      Conserved Domains (1) summary
      pfam00021
      Location:141 → 210
      UPAR_LY6; u-PAR/Ly-6 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24408645..24413960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539843.3 → XP_006539906.1  ly6/PLAUR domain containing 10 isoform X1

      See identical proteins and their annotated locations for XP_006539906.1

      UniProtKB/TrEMBL
      Q810N3
      Conserved Domains (1) summary
      pfam00021
      Location:141 → 210
      UPAR_LY6; u-PAR/Ly-6 domain

    2. XM_006539844.3 → XP_006539907.1  ly6/PLAUR domain containing 10 isoform X1

      See identical proteins and their annotated locations for XP_006539907.1

      UniProtKB/TrEMBL
      Q810N3
      Conserved Domains (1) summary
      pfam00021
      Location:141 → 210
      UPAR_LY6; u-PAR/Ly-6 domain

    3. XM_006539848.3 → XP_006539911.1  ly6/PLAUR domain containing 10 isoform X1

      See identical proteins and their annotated locations for XP_006539911.1

      UniProtKB/TrEMBL
      Q810N3
      Conserved Domains (1) summary
      pfam00021
      Location:141 → 210
      UPAR_LY6; u-PAR/Ly-6 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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