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    Gpd1l glycerol-3-phosphate dehydrogenase 1-like [ Mus musculus (house mouse) ]

    Gene ID: 333433, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Gpd1lprovided by MGI
    Official Full Name
    glycerol-3-phosphate dehydrogenase 1-likeprovided by MGI
    Primary source
    MGI:MGI:1289257
    See related
    Ensembl:ENSMUSG00000050627 AllianceGenome:MGI:1289257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D9Ertd660e; 2210409H23Rik
    Summary
    Predicted to enable sodium channel regulator activity and transmembrane transporter binding activity. Acts upstream of or within NADH metabolic process. Located in membrane. Is expressed in alimentary system and nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 16.6), large intestine adult (RPKM 16.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpd1l in Genome Data Viewer
    Location:
    9 F3; 9 65.47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114728407..114763055, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114899339..114933987, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CKLF-like MARVEL transmembrane domain containing 8 Neighboring gene predicted gene, 23889 Neighboring gene predicted gene, 30448 Neighboring gene STARR-positive B cell enhancer ABC_E6808 Neighboring gene oxysterol binding protein-like 10 Neighboring gene ribosomal protein S27, retrogene Neighboring gene STARR-seq mESC enhancer starr_25396 Neighboring gene STARR-seq mESC enhancer starr_25397 Neighboring gene STARR-positive B cell enhancer mm9_chr9:114953001-114953302 Neighboring gene predicted gene 4665

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias. London B, et al. Circulation, 2007 Nov 13. PMID 17967977, Free PMC Article
    2. Cardiac Na+ current regulation by pyridine nucleotides. Liu M, et al. Circ Res, 2009 Oct 9. PMID 19745168, Free PMC Article
    3. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422
    4. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Watkins DS, et al. Proteomes, 2018 Dec 17. PMID 30562941, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within NADH metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycerol-3-phosphate dehydrogenase (FAD) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate dehydrogenase 1-like protein
    NP_780589.3
    XP_036010981.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175380.5 → NP_780589.3  glycerol-3-phosphate dehydrogenase 1-like protein

      See identical proteins and their annotated locations for NP_780589.3

      Status: VALIDATED

      Source sequence(s)
      AC127573, AK172886, BC138980, BY369485
      Consensus CDS
      CCDS23598.1
      UniProtKB/Swiss-Prot
      Q3ULJ0, Q6A0D2, Q8BVZ7, Q8BWM5, Q8CFN6
      UniProtKB/TrEMBL
      B2RSR7
      Related
      ENSMUSP00000117509.2, ENSMUST00000146623.8
      Conserved Domains (3) summary
      TIGR03376
      Location:7 → 344
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:7 → 175
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:198 → 337
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      114728407..114763055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155088.1 → XP_036010981.1  glycerol-3-phosphate dehydrogenase 1-like protein isoform X1

      Conserved Domains (1) summary
      TIGR03376
      Location:1 → 305
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ULJ0.2 GenPept UniProtKB/Swiss-Prot:Q3ULJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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