PTGFRN prostaglandin F2 receptor inhibitor [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTGFRNprovided by HGNC
Official Full Name: prostaglandin F2 receptor inhibitorprovided by HGNC
Primary source: HGNC:HGNC:9601
See related: Ensembl:ENSG00000134247 MIM:601204; AllianceGenome:HGNC:9601
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FPRP; CD315; EWI-F; CD9P-1; SMAP-6
Summary: Predicted to be involved in myoblast fusion involved in skeletal muscle regeneration. Predicted to act upstream of or within lipid droplet organization. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart (RPKM 21.3), endometrium (RPKM 18.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p13.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (116909916..116990353)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (116920364..117000790)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (117452538..117532975)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development.
Title: Identification of Prostaglandin F2 Receptor Negative Regulator (PTGFRN) as an internalizable target in cancer cells for antibody-drug conjugate development.
High PTGFRN expression is associated with glioblastoma multiforme.
Title: The Ig superfamily protein PTGFRN coordinates survival signaling in glioblastoma multiforme.
These findings show for the first time that CD9P-1 expression positively correlates with the metastatic status of human lung tumor
Title: CD9P-1 expression correlates with the metastatic status of lung cancer, and a truncated form of CD9P-1, GS-168AT2, inhibits in vivo tumour growth.
Tetraspanins can play a role on CD9P-1 oligomerization status.
Title: In situ chemical cross-linking on living cells reveals CD9P-1 cis-oligomer at cell surface.
Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
CD9P-1 was shown to exhibit more than 40 different N-glycans, essentially composed of complex and high mannose-type structures.
Title: Glycosylation status of the membrane protein CD9P-1.
transferrin receptor and CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells
Title: The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.
EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins
Title: EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins.
EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization
Title: Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of prostaglandin F2 receptor inhibitor (PTGFRN) in peptide-treated PBMCs	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S2203 (e-PCR)
- UniSTS:11607

SHGC-75389 (e-PCR)
- UniSTS:37731

U26664 (e-PCR)
- UniSTS:7031

RH91725 (e-PCR)
- UniSTS:83600

SGC33573 (e-PCR)
- UniSTS:83135

G34883 (e-PCR)
- UniSTS:22463

SHGC-75388 (e-PCR)
- UniSTS:23232

D1S3546 (e-PCR)
- UniSTS:21957

SHGC-75379 (e-PCR)
- UniSTS:75225

D1S2198 (e-PCR)
- UniSTS:254

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid droplet organization	IEA Inferred from Electronic Annotation more info
involved_in myoblast fusion involved in skeletal muscle regeneration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell surface	HDA more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin F2 receptor negative regulator

Names: CD9 partner 1; glu-Trp-Ile EWI motif-containing protein F; prostaglandin F2-alpha receptor regulatory protein; prostaglandin F2-alpha receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.