Wdtc1 WD and tetratricopeptide repeats 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdtc1provided by MGI
Official Full Name: WD and tetratricopeptide repeats 1provided by MGI
Primary source: MGI:MGI:2685541
See related: Ensembl:ENSMUSG00000037622 AllianceGenome:MGI:2685541
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: adp; Gm695; adipose
Summary: Enables enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of cellular biosynthetic process. Located in cytosol and nucleus. Is expressed in heart left ventricle; heart right ventricle; left lung; pancreas; and right lung. Orthologous to human WDTC1 (WD and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 115.3), duodenum adult (RPKM 49.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.25 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133019777..133080811, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133292466..133353469, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma.
Title: ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma.
Adp is a positive modulator of myoblast differentiation.
Title: Adipose induces myoblast differentiation and mediates TNFα-regulated myogenesis.
Data show that the anti-obesity function of adipose (Adp) (worm Y73E7A.9, fly adp, and murine Wdtc1) is conserved from worms to mammals.
Title: Adipose is a conserved dosage-sensitive antiobesity gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular chemical homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD and tetratricopeptide repeats protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416526.1 → NP_001403455.1 WD and tetratricopeptide repeats protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL671882

UniProtKB/Swiss-Prot

Q80ZK9
NM_001416528.1 → NP_001403457.1 WD and tetratricopeptide repeats protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL671882

UniProtKB/Swiss-Prot

Q80ZK9
NM_001416529.1 → NP_001403458.1 WD and tetratricopeptide repeats protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL671882
NM_001416531.1 → NP_001403460.1 WD and tetratricopeptide repeats protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL671882
NM_001416532.1 → NP_001403461.1 WD and tetratricopeptide repeats protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL671882
NM_001416533.1 → NP_001403462.1 WD and tetratricopeptide repeats protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL671882
NM_001416534.1 → NP_001403463.1 WD and tetratricopeptide repeats protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL671882
NM_199306.4 → NP_955010.1 WD and tetratricopeptide repeats protein 1 isoform 1

See identical proteins and their annotated locations for NP_955010.1

Status: VALIDATED

Source sequence(s)

AL671882

Consensus CDS

CCDS18746.1

UniProtKB/Swiss-Prot

Q80ZK9

UniProtKB/TrEMBL

A2AE98

Related

ENSMUSP00000040647.8, ENSMUST00000043305.14

Conserved Domains (4) summary

PLN03088
Location:367 → 437

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:365 → 389

TPR; TPR repeat [structural motif]

sd00039
Location:51 → 88

7WD40; WD40 repeat [structural motif]

cl29593
Location:34 → 163

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...