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    nop5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33966, updated on 10-May-2024

    Summary

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    Official Symbol
    nop5provided by FlyBase
    Primary source
    FLYBASE:FBgn0026196
    Locus tag
    Dmel_CG10206
    See related
    AllianceGenome:FB:FBgn0026196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2/30; CG10206; Dmel\CG10206; Dnop5; DNOP5; Nop5; NOP5
    Summary
    Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; gut section; imaginal disc; and visceral muscle primordium. Orthologous to human NOP58 (NOP58 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See nop5 in Genome Data Viewer
    Location:
    27C4-27C4; 2-23 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6916753..6918743, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6916753..6918743, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rat1 5'-3' exoribonuclease Neighboring gene ncRNA Neighboring gene Wee1 kinase Neighboring gene uncharacterized protein Neighboring gene x16 splicing factor Neighboring gene Heterogeneous nuclear ribonucleoprotein at 27C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila. Murata T, et al. Biosci Biotechnol Biochem, 2008 Sep. PMID 18776683
    2. Restricted expression and subnuclear localization of the Drosophila gene Dnop5, a member of the Nop/Sik family of the conserved rRNA processing factors. Vorbrüggen G, et al. Mech Dev, 2000 Feb. PMID 10640717
    3. Localized expression of the Drosophila gene Dxl6, a novel member of the serine/arginine rich (SR) family of splicing factors. Vorbrüggen G, et al. Mech Dev, 2000 Feb. PMID 10640718
    4. Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts. Hovhanyan A, et al. Mol Cell Biol, 2014 May. PMID 24615015, Free PMC Article
    5. The EGF/Ras pathway controls growth in Drosophila via ribosomal RNA synthesis. Sriskanthadevan-Pirahas S, et al. Dev Biol, 2018 Jul 1. PMID 29660312

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nop5
    Names
    CG10206-PA
    nop5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6916753..6918743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058064.5 → NP_477412.1  nop5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0ANY9, Q9U5W4, Q9VM69
      Related
      FBpp0078997
      Conserved Domains (3) summary
      smart00931
      Location:163 → 214
      NOSIC; NOSIC (NUC001) domain
      pfam01798
      Location:169 → 397
      Nop; snoRNA binding domain, fibrillarin
      pfam08156
      Location:2 → 52
      NOP5NT; NOP5NT (NUC127) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U5W4 Q9U5W4
    Q9VM69 Q9VM69

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