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    Psf2 Partner of Sld Five 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33641, updated on 10-May-2024

    Summary

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    Official Symbol
    Psf2provided by FlyBase
    Official Full Name
    Partner of Sld Five 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0261976
    Locus tag
    Dmel_CG18013
    See related
    AllianceGenome:FB:FBgn0261976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18013; Dmel\CG18013; l(2)SH0805; l(2)SH2 0805; PSF2; P{lacW}l(2)SH0805[SH0805]
    Summary
    Involved in chromosome condensation. Part of CMG complex and GINS complex. Is expressed in organism. Orthologous to human GINS2 (GINS complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Psf2 in Genome Data Viewer
    Location:
    24E4-24E4; 2-12 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4386182..4387356, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4386182..4387356, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 53 Neighboring gene Trehalose-6-phosphate synthase 1 Neighboring gene uncharacterized protein Neighboring gene lethal (2) k05819

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Psf2 has a role in chromosome condensation. Chmielewski JP, et al. Chromosoma, 2012 Dec. PMID 22993141, Free PMC Article
    2. Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression. Gosnell JA, et al. BMC Mol Biol, 2011 Apr 6. PMID 21470422, Free PMC Article
    3. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Gouge CA, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20709026, Free PMC Article
    4. DNA replication machinery contributes to development of eye in Drosophila. Kohzaki H, et al. Front Biosci (Landmark Ed), 2018 Jan 1. PMID 28930558
    5. Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. Beumer KJ, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979928, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in DNA strand elongation involved in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    partner of Sld five 2
    Names
    CG18013-PB
    CG18013-PC
    Psf2-PB
    Psf2-PC
    lethal (2) SH0805

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4386182..4387356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273093.1 → NP_001260022.1  partner of Sld five 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260022.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PB28, Q8SYY9, Q9VQY9
      Conserved Domains (2) summary
      cd11712
      Location:55 → 174
      GINS_A_psf2; Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)
      cd21694
      Location:2 → 63
      GINS_B_Psf2; beta-strand (B) domain of GINS complex protein Psf2

    2. NM_134982.3 → NP_608826.4  partner of Sld five 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608826.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PB28, Q8SYY9, Q9VQY9
      Conserved Domains (2) summary
      cd11712
      Location:55 → 174
      GINS_A_psf2; Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)
      cd21694
      Location:2 → 63
      GINS_B_Psf2; beta-strand (B) domain of GINS complex protein Psf2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6RAW_L.1
    6RAX_L.1
    6RAY_L.1
    6RAZ_L.1
    Q9VQY9.1 Q9VQY9

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