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    Btbd10 BTB domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 68815, updated on 7-May-2024

    Summary

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    Official Symbol
    Btbd10provided by MGI
    Official Full Name
    BTB domain containing 10provided by MGI
    Primary source
    MGI:MGI:1916065
    See related
    Ensembl:ENSMUSG00000038187 AllianceGenome:MGI:1916065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gmrp1; 1110056N09Rik
    Summary
    Involved in negative regulation of neuron death and positive regulation of phosphorylation. Located in cytoplasm. Orthologous to human BTBD10 (BTB domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 11.6), CNS E18 (RPKM 7.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Btbd10 in Genome Data Viewer
    Location:
    7 F1; 7 59.18 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (112914838..112970734, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (113315631..113371527, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930543E12 gene Neighboring gene STARR-seq mESC enhancer starr_19892 Neighboring gene STARR-seq mESC enhancer starr_19896 Neighboring gene STARR-seq mESC enhancer starr_19898 Neighboring gene STARR-positive B cell enhancer ABC_E157 Neighboring gene basic helix-loop-helix ARNT like 1 Neighboring gene STARR-seq mESC enhancer starr_19903 Neighboring gene STARR-seq mESC enhancer starr_19904 Neighboring gene predicted gene, 33721 Neighboring gene STARR-positive B cell enhancer ABC_E11364 Neighboring gene STARR-positive B cell enhancer ABC_E3744 Neighboring gene STARR-positive B cell enhancer ABC_E9297 Neighboring gene parathyroid hormone Neighboring gene STARR-seq mESC enhancer starr_19909 Neighboring gene BCL2-associated transcription factor 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Nawa M, et al. Cell Signal, 2008 Mar. PMID 18160256
    2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to amyotrophic lateral sclerosis and an enhancer of cell growth via its positive regulation of Akt phosphorylation.
      Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 10
    Names
    BTB (POZ) domain containing 10
    K+ channel tetramerization protein
    glucose metabolism-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133700.3 → NP_598461.1  BTB/POZ domain-containing protein 10

      See identical proteins and their annotated locations for NP_598461.1

      Status: VALIDATED

      Source sequence(s)
      AC156605, AC156987
      Consensus CDS
      CCDS21755.1
      UniProtKB/Swiss-Prot
      Q80X66
      Related
      ENSMUSP00000048530.8, ENSMUST00000047091.14
      Conserved Domains (1) summary
      cd18385
      Location:165 → 274
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      112914838..112970734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508162.3 → XP_006508225.1  BTB/POZ domain-containing protein 10 isoform X3

      See identical proteins and their annotated locations for XP_006508225.1

      UniProtKB/TrEMBL
      E9Q6L8
      Related
      ENSMUSP00000113632.2, ENSMUST00000119278.8
      Conserved Domains (1) summary
      cd18385
      Location:117 → 226
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    2. XM_006508160.3 → XP_006508223.1  BTB/POZ domain-containing protein 10 isoform X2

      See identical proteins and their annotated locations for XP_006508223.1

      UniProtKB/Swiss-Prot
      Q80X66
      Conserved Domains (1) summary
      cd18385
      Location:165 → 274
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    3. XM_006508161.3 → XP_006508224.1  BTB/POZ domain-containing protein 10 isoform X3

      See identical proteins and their annotated locations for XP_006508224.1

      UniProtKB/TrEMBL
      E9Q6L8
      Conserved Domains (1) summary
      cd18385
      Location:117 → 226
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    4. XM_006508163.3 → XP_006508226.1  BTB/POZ domain-containing protein 10 isoform X3

      See identical proteins and their annotated locations for XP_006508226.1

      UniProtKB/TrEMBL
      E9Q6L8
      Conserved Domains (1) summary
      cd18385
      Location:117 → 226
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    5. XM_011241890.3 → XP_011240192.1  BTB/POZ domain-containing protein 10 isoform X2

      See identical proteins and their annotated locations for XP_011240192.1

      UniProtKB/Swiss-Prot
      Q80X66
      Conserved Domains (1) summary
      cd18385
      Location:165 → 274
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    6. XM_006508159.5 → XP_006508222.1  BTB/POZ domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      E9Q6Y9
      Related
      ENSMUSP00000113496.2, ENSMUST00000117577.8
      Conserved Domains (1) summary
      cd18385
      Location:173 → 282
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80X66.1 GenPept UniProtKB/Swiss-Prot:Q80X66

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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