U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    alg-4 Putative protein tag-76 [ Caenorhabditis elegans ]

    Gene ID: 176400, updated on 25-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    alg-4
    Gene description
    Putative protein tag-76
    Primary source
    WormBase:WBGene00006449
    Locus tag
    CELE_ZK757.3
    See related
    AllianceGenome:WB:WBGene00006449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleic acid binding activity. Involved in spermatogenesis. Predicted to be located in P granule. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See alg-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (9887210..9891424, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Snake toxin/toxin-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ubiquitinyl hydrolase 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Maternal and zygotic gene regulatory effects of endogenous RNAi pathways. Almeida MV, et al. PLoS Genet, 2019 Feb. PMID 30759082, Free PMC Article
    2. Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Conine CC, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133686, Free PMC Article
    3. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Conine CC, et al. Cell, 2013 Dec 19. PMID 24360276, Free PMC Article
    4. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Cox DN, et al. Genes Dev, 1998 Dec 1. PMID 9851978, Free PMC Article
    5. 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Han T, et al. Proc Natl Acad Sci U S A, 2009 Nov 3. PMID 19846761, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that the CSR-1 Argonaute functions with ALG-3/4 to positively regulate target genes required for spermiogenesis; these findings are consistent with a model in which ALG-3/4 and CSR-1 and their associated small RNAs provide an epigenetic memory of paternal gene expression, thereby ensuring the transgenerational continuity of a robust spermiogenic program.
      Title: Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans.
    2. the role of two argonautes-class paralogs, alg-3 (T22B3.2) and alg-4 (ZK757.3), in promoting thermotolerant male fertility was described.
      Title: Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Putative protein tag-76
    NP_499191.1
    • Confirmed by transcript evidence
    NP_499192.1
    • Confirmed by transcript evidence
    NP_499193.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9887210..9891424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066790.5 → NP_499191.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681, Q7JMT0, Q9TW94
      Conserved Domains (5) summary
      PLN03202
      Location:67 → 959
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:374 → 484
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:530 → 964
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:266 → 306
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:89 → 235
      ArgoN; N-terminal domain of argonaute

    2. NM_066791.6 → NP_499192.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681
      Conserved Domains (5) summary
      PLN03202
      Location:64 → 956
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:371 → 481
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:527 → 961
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:263 → 303
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:86 → 232
      ArgoN; N-terminal domain of argonaute

    3. NM_066792.4 → NP_499193.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499193.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34681.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.