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    Islr immunoglobulin superfamily containing leucine-rich repeat [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686539, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Islrprovided by RGD
    Official Full Name
    immunoglobulin superfamily containing leucine-rich repeatprovided by RGD
    Primary source
    RGD:1596359
    See related
    Ensembl:ENSRNOG00000048924 AllianceGenome:RGD:1596359
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Orthologous to human ISLR (immunoglobulin superfamily containing leucine rich repeat). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 170.9), Uterus (RPKM 165.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Islr in Genome Data Viewer
    Location:
    8q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67467013..67469989, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58571155..58574128, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62946732..62949675, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 33 Neighboring gene uncharacterized LOC120094173 Neighboring gene signaling receptor and transporter of retinol STRA6 Neighboring gene uncharacterized LOC134480059 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    immunoglobulin superfamily containing leucine-rich repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126300.1 → NP_001119772.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

      See identical proteins and their annotated locations for NP_001119772.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160841
      UniProtKB/TrEMBL
      A0A8I6AEA4, A6J4Z4, B1H232
      Related
      ENSRNOP00000090688.1, ENSRNOT00000106345.1
      Conserved Domains (5) summary
      TIGR00864
      Location:153 → 227
      PCC; polycystin cation channel protein
      sd00033
      Location:32 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 158
      LRR_8; Leucine rich repeat
      cd00096
      Location:265 → 287
      Ig; Ig strand C [structural motif]
      cl11960
      Location:239 → 343
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      67467013..67469989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243176.5 → XP_006243238.1  immunoglobulin superfamily containing leucine-rich repeat protein isoform X1

      See identical proteins and their annotated locations for XP_006243238.1

      UniProtKB/TrEMBL
      A0A8I6AEA4, A6J4Z4, B1H232
      Related
      ENSRNOP00000067644.1
      Conserved Domains (5) summary
      TIGR00864
      Location:153 → 227
      PCC; polycystin cation channel protein
      sd00033
      Location:32 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 158
      LRR_8; Leucine rich repeat
      cd00096
      Location:265 → 287
      Ig; Ig strand C [structural motif]
      cl11960
      Location:239 → 343
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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