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    Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 23971, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Papss1provided by MGI
    Official Full Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 1provided by MGI
    Primary source
    MGI:MGI:1330587
    See related
    Ensembl:ENSMUSG00000028032 AllianceGenome:MGI:1330587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SK1; Asapk
    Summary
    Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Acts upstream of or within 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process. Predicted to be part of sulfate adenylyltransferase complex (ATP). Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 34.0), genital fat pad adult (RPKM 31.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Papss1 in Genome Data Viewer
    Location:
    3 G3; 3 61.05 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (131270626..131349432)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (131564764..131643671)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sphingomyelin synthase 2 Neighboring gene STARR-seq mESC enhancer starr_09007 Neighboring gene predicted gene, 36753 Neighboring gene predicted gene, 36863 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:131227425-131227534 Neighboring gene predicted gene, 36917 Neighboring gene STARR-seq mESC enhancer starr_09009 Neighboring gene STARR-seq mESC enhancer starr_09010 Neighboring gene olfactory receptor 375, pseudogene 1 Neighboring gene predicted gene, 29865 Neighboring gene STARR-seq mESC enhancer starr_09011 Neighboring gene predicted gene, 29949

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. Deyrup AT, et al. J Biol Chem, 1998 Apr 17. PMID 9545271
    2. Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase. Singh B, et al. J Biol Chem, 2003 Jan 3. PMID 12414806
    3. Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm. Schröder E, et al. PLoS One, 2012. PMID 22242175, Free PMC Article
    4. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization. Xu ZH, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679223
    5. A member of a family of sulfate-activating enzymes causes murine brachymorphism. Kurima K, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671738, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data illustrate the functional importance of several highly conserved residues in the active site of phosphoadenosine phosphosulfate synthetase.
      Title: Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylylsulfate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylylsulfate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate adenylyltransferase (ATP) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of sulfate adenylyltransferase complex (ATP) IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
    Names
    PAPS synthase 1
    sulfurylase kinase 1
    NP_001276406.1
    NP_001276407.1
    NP_001276408.1
    NP_001397506.1
    NP_001397507.1
    NP_001397508.1
    NP_035993.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289477.2 → NP_001276406.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

      See identical proteins and their annotated locations for NP_001276406.1

      Status: VALIDATED

      Source sequence(s)
      AC127686
      Consensus CDS
      CCDS80023.1
      UniProtKB/TrEMBL
      Q6NZM8
      Conserved Domains (2) summary
      cd00517
      Location:233 → 596
      ATPS; ATP-sulfurylase
      cd02027
      Location:33 → 183
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

    2. NM_001289478.2 → NP_001276407.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

      See identical proteins and their annotated locations for NP_001276407.1

      Status: VALIDATED

      Source sequence(s)
      AC127686
      Consensus CDS
      CCDS80023.1
      UniProtKB/TrEMBL
      Q6NZM8
      Related
      ENSMUSP00000142533.2, ENSMUST00000199878.5
      Conserved Domains (2) summary
      cd00517
      Location:233 → 596
      ATPS; ATP-sulfurylase
      cd02027
      Location:33 → 183
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

    3. NM_001289479.2 → NP_001276408.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform c

      See identical proteins and their annotated locations for NP_001276408.1

      Status: VALIDATED

      Source sequence(s)
      AC127686
      UniProtKB/TrEMBL
      Q3TUA8
      Conserved Domains (3) summary
      cd00517
      Location:185 → 548
      ATPS; ATP-sulfurylase
      cd02027
      Location:1 → 135
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
      TIGR00339
      Location:164 → 547
      sopT; ATP sulphurylase

    4. NM_001410577.1 → NP_001397506.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC127686
      UniProtKB/TrEMBL
      Q6NZM8
      Related
      ENSMUSP00000142616.2, ENSMUST00000200527.5

    5. NM_001410578.1 → NP_001397507.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC127686
      UniProtKB/TrEMBL
      Q6NZM8

    6. NM_001410579.1 → NP_001397508.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC127686
      UniProtKB/TrEMBL
      Q6NZM8

    7. NM_011863.3 → NP_035993.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform a

      See identical proteins and their annotated locations for NP_035993.1

      Status: VALIDATED

      Source sequence(s)
      AC127686
      Consensus CDS
      CCDS38641.1
      UniProtKB/Swiss-Prot
      Q3U647, Q60967
      Related
      ENSMUSP00000029666.10, ENSMUST00000029666.14
      Conserved Domains (3) summary
      cd00517
      Location:254 → 617
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:233 → 616
      sopT; ATP sulphurylase
      pfam01583
      Location:51 → 205
      APS_kinase; Adenylylsulphate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      131270626..131349432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60967.1 GenPept UniProtKB/Swiss-Prot:Q60967

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