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    Ccr4 C-C motif chemokine receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 12773, updated on 27-May-2024

    Summary

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    Official Symbol
    Ccr4provided by MGI
    Official Full Name
    C-C motif chemokine receptor 4provided by MGI
    Primary source
    MGI:MGI:107824
    See related
    Ensembl:ENSMUSG00000047898 AllianceGenome:MGI:107824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4
    Summary
    Enables C-C chemokine receptor activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuron migration; and tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; intestine; pyloric antrum; reproductive system; and thymus. Orthologous to human CCR4 (C-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 10.4), testis adult (RPKM 1.5) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccr4 in Genome Data Viewer
    Location:
    9 F3; 9 64.49 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114319384..114334544, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114490316..114505476, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5109 Neighboring gene STARR-positive B cell enhancer mm9_chr9:114327339-114327639 Neighboring gene transmembrane protein with metallophosphoesterase domain Neighboring gene galactosidase, beta 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114345054-114345237 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114352487-114352773 Neighboring gene predicted gene, 30254 Neighboring gene STARR-seq mESC enhancer starr_25350 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114419096-114419279 Neighboring gene tripartite motif-containing 71 Neighboring gene STARR-seq mESC enhancer starr_25364 Neighboring gene STARR-seq mESC enhancer starr_25369 Neighboring gene STARR-seq mESC enhancer starr_25371 Neighboring gene STARR-seq mESC enhancer starr_25375 Neighboring gene predicted gene, 53512 Neighboring gene CCR4-NOT transcription complex, subunit 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis. Honzawa T, et al. Int Immunol, 2022 Dec 31. PMID 35997787
    2. Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons. Silva JR, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35046040, Free PMC Article
    3. CCR4 Involvement in the Expansion of T Helper Type 17 Cells in a Mouse Model of Psoriasis. Matsuo K, et al. J Invest Dermatol, 2021 Aug. PMID 33662381
    4. Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice. Deng S, et al. Neurotherapeutics, 2020 Oct. PMID 32783091, Free PMC Article
    5. Blockade of CCR4 Diminishes Hypersensitivity and Enhances Opioid Analgesia - Evidence from a Mouse Model of Diabetic Neuropathy. Bogacka J, et al. Neuroscience, 2020 Aug 10. PMID 32592824

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model.
      Title: Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model.
    2. CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.
      Title: CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.
    3. CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis.
      Title: CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis.
    4. Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons.
      Title: Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons.
    5. CCR4 Involvement in the Expansion of T Helper Type 17 Cells in a Mouse Model of Psoriasis.
      Title: CCR4 Involvement in the Expansion of T Helper Type 17 Cells in a Mouse Model of Psoriasis.
    6. Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice.
      Title: Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice.
    7. Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4.
      Title: Tumors establish resistance to immunotherapy by regulating T(reg) recruitment via CCR4.
    8. Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
      Title: Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
    9. Blockade of CCR4 Diminishes Hypersensitivity and Enhances Opioid Analgesia - Evidence from a Mouse Model of Diabetic Neuropathy.
      Title: Blockade of CCR4 Diminishes Hypersensitivity and Enhances Opioid Analgesia - Evidence from a Mouse Model of Diabetic Neuropathy.
    10. Dendritic cells and regulatory T cells expressing CCR4 provide resistance to coxsackievirus B5-induced pancreatitis.
      Title: Dendritic cells and regulatory T cells expressing CCR4 provide resistance to coxsackievirus B5-induced pancreatitis.
    Submit: New GeneRIF Correction See all GeneRIFs (60)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151418

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interneuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-C chemokine receptor type 4
    Names
    chemokine (C-C motif) receptor 4
    chemokine (C-C) receptor 4
    fusin
    leukocyte-expressed seven-transmembrane-domain receptor
    NP_034046.2
    XP_006511995.1
    XP_006511996.1
    XP_006511997.1
    XP_011241235.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009916.2 → NP_034046.2  C-C chemokine receptor type 4

      See identical proteins and their annotated locations for NP_034046.2

      Status: VALIDATED

      Source sequence(s)
      AC164109, BC119171
      Consensus CDS
      CCDS23594.1
      UniProtKB/Swiss-Prot
      P51680, Q14A03
      Related
      ENSMUSP00000062677.4, ENSMUST00000054414.5
      Conserved Domains (1) summary
      cd14984
      Location:40 → 315
      7tmA_Chemokine_R; classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      114319384..114334544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511934.4 → XP_006511997.1  C-C chemokine receptor type 4 isoform X2

      See identical proteins and their annotated locations for XP_006511997.1

      UniProtKB/Swiss-Prot
      P51680, Q14A03
      Conserved Domains (1) summary
      cd14984
      Location:40 → 315
      7tmA_Chemokine_R; classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_006511932.4 → XP_006511995.1  C-C chemokine receptor type 4 isoform X1

      Conserved Domains (1) summary
      cd14984
      Location:147 → 422
      7tmA_Chemokine_R; classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_011242933.3 → XP_011241235.1  C-C chemokine receptor type 4 isoform X2

      See identical proteins and their annotated locations for XP_011241235.1

      UniProtKB/Swiss-Prot
      P51680, Q14A03
      Conserved Domains (1) summary
      cd14984
      Location:40 → 315
      7tmA_Chemokine_R; classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_006511933.2 → XP_006511996.1  C-C chemokine receptor type 4 isoform X2

      See identical proteins and their annotated locations for XP_006511996.1

      UniProtKB/Swiss-Prot
      P51680, Q14A03
      Related
      ENSMUSP00000150002.2, ENSMUST00000215425.2
      Conserved Domains (1) summary
      cd14984
      Location:40 → 315
      7tmA_Chemokine_R; classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51680.2 GenPept UniProtKB/Swiss-Prot:P51680

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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