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    Hrob homologous recombination factor with OB-fold [ Mus musculus (house mouse) ]

    Gene ID: 217216, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hrobprovided by MGI
    Official Full Name
    homologous recombination factor with OB-foldprovided by MGI
    Primary source
    MGI:MGI:2387601
    See related
    Ensembl:ENSMUSG00000034773 AllianceGenome:MGI:2387601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables single-stranded DNA binding activity. Involved in female gamete generation and male gamete generation. Predicted to be located in site of DNA damage. Orthologous to human HROB (homologous recombination factor with OB-fold). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 16.1), liver E14.5 (RPKM 5.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hrob in Genome Data Viewer
    Location:
    11 D; 11 66.21 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102139677..102156009)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102248857..102265183)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glucose 6 phosphatase, catalytic, 3 Neighboring gene histone deacetylase 5 Neighboring gene STARR-positive B cell enhancer ABC_E378 Neighboring gene microRNA 8101 Neighboring gene STARR-positive B cell enhancer ABC_E911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102128926-102129035 Neighboring gene ankyrin repeat and SOCS box-containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E1432 Neighboring gene transmembrane and ubiquitin-like domain containing 2 Neighboring gene ataxin 7-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes. Tucker EJ, et al. Eur J Hum Genet, 2022 Feb. PMID 34707299, Free PMC Article
    2. Control of homologous recombination by the HROB-MCM8-MCM9 pathway. Hustedt N, et al. Genes Dev, 2019 Oct 1. PMID 31467087, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes.
      Title: Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • MGC31269, MGC117894

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in recombinational repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homologous recombination OB-fold protein
    Names
    uncharacterized protein C17orf53 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153544.3 → NP_705772.3  homologous recombination OB-fold protein

      See identical proteins and their annotated locations for NP_705772.3

      Status: VALIDATED

      Source sequence(s)
      AK029811, AL954730, BB610688
      Consensus CDS
      CCDS36342.1
      UniProtKB/Swiss-Prot
      A2AWS8, Q32P12, Q8CDN3
      Related
      ENSMUSP00000097961.5, ENSMUST00000100392.5
      Conserved Domains (2) summary
      PHA03195
      Location:17 → 80
      PHA03195; tegument protein VP11/12; Provisional
      pfam15072
      Location:458 → 539
      DUF4539; Domain of unknown function (DUF4539)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102139677..102156009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533040.3 → XP_006533103.1  homologous recombination OB-fold protein isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:44 → 374
      PHA03247; large tegument protein UL36; Provisional
      pfam15072
      Location:459 → 540
      DUF4539; Domain of unknown function (DUF4539)

    2. XM_030245876.1 → XP_030101736.1  homologous recombination OB-fold protein isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:135 → 294
      PHA03247; large tegument protein UL36; Provisional
      pfam15072
      Location:379 → 460
      DUF4539; Domain of unknown function (DUF4539)

    3. XM_036156591.1 → XP_036012484.1  homologous recombination OB-fold protein isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:135 → 294
      PHA03247; large tegument protein UL36; Provisional
      pfam15072
      Location:378 → 459
      DUF4539; Domain of unknown function (DUF4539)

    4. XM_030245878.1 → XP_030101738.1  homologous recombination OB-fold protein isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:135 → 294
      PHA03247; large tegument protein UL36; Provisional
      pfam15072
      Location:379 → 460
      DUF4539; Domain of unknown function (DUF4539)

    5. XM_017314483.3 → XP_017169972.1  homologous recombination OB-fold protein isoform X4

      Conserved Domains (1) summary
      pfam15072
      Location:94 → 175
      DUF4539; Domain of unknown function (DUF4539)

    RNA

    1. XR_004936928.1 RNA Sequence

    2. XR_004936929.1 RNA Sequence

      Related
      ENSMUST00000133930.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32P12.2 GenPept UniProtKB/Swiss-Prot:Q32P12

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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