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    Trmt61a tRNA methyltransferase 61A [ Mus musculus (house mouse) ]

    Gene ID: 328162, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Trmt61aprovided by MGI
    Official Full Name
    tRNA methyltransferase 61Aprovided by MGI
    Primary source
    MGI:MGI:2443487
    See related
    Ensembl:ENSMUSG00000060950 AllianceGenome:MGI:2443487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcd14; Trm61; 6720458F09Rik
    Summary
    Predicted to enable mRNA (adenine-N1-)-methyltransferase activity. Predicted to be involved in mRNA methylation and tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.2), adrenal adult (RPKM 12.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt61a in Genome Data Viewer
    Location:
    12 F1; 12 61.09 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111644539..111650336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111678105..111683902)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7187 Neighboring gene MAP/microtubule affinity regulating kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E10775 Neighboring gene creatine kinase, brain Neighboring gene VISTA enhancer mm1606 Neighboring gene predicted gene, 51961 Neighboring gene predicted gene, 36635

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis. Liu Y, et al. Nat Immunol, 2022 Oct. PMID 36138184
    2. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. Ozanick S, et al. RNA, 2005 Aug. PMID 16043508, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tRNA-m[1]A modification promotes T cell expansion via efficient MYC protein synthesis.
      Title: tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis.
    2. Shows conservation of the yeast TRM61 (GCD14) protein in mouse, human and Drosophila, and demonstrates functional activity of the human ortholog.
      Title: The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA (adenine-N1-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
    Names
    mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
    tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
    tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
    tRNA methyltransferase 61 homolog A
    tRNA(m1A58)-methyltransferase subunit TRM61
    tRNA(m1A58)-methyltransferase subunit TRMT61A
    tRNA(m1A58)MTase subunit TRM61
    tRNA(m1A58)MTase subunit TRMT61A
    NP_001093262.1
    NP_001093263.1
    NP_796348.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099792.1 → NP_001093262.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

      See identical proteins and their annotated locations for NP_001093262.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI447734, BC051186, BY122337, BY345591
      Consensus CDS
      CCDS26184.1
      UniProtKB/Swiss-Prot
      Q80XC2, Q8BMD4, Q8BX33
      Related
      ENSMUSP00000133128.2, ENSMUST00000168338.2
      Conserved Domains (3) summary
      COG2519
      Location:9 → 290
      Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
      pfam08704
      Location:64 → 287
      GCD14; tRNA methyltransferase complex GCD14 subunit
      pfam14801
      Location:12 → 58
      GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

    2. NM_001099793.1 → NP_001093263.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

      See identical proteins and their annotated locations for NP_001093263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI447734, BB868135, BC051186
      Consensus CDS
      CCDS26184.1
      UniProtKB/Swiss-Prot
      Q80XC2, Q8BMD4, Q8BX33
      Conserved Domains (3) summary
      COG2519
      Location:9 → 290
      Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
      pfam08704
      Location:64 → 287
      GCD14; tRNA methyltransferase complex GCD14 subunit
      pfam14801
      Location:12 → 58
      GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

    3. NM_177374.4 → NP_796348.2  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

      See identical proteins and their annotated locations for NP_796348.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI447734, BC051186, BY122337
      Consensus CDS
      CCDS26184.1
      UniProtKB/Swiss-Prot
      Q80XC2, Q8BMD4, Q8BX33
      Related
      ENSMUSP00000082011.4, ENSMUST00000084947.10
      Conserved Domains (3) summary
      COG2519
      Location:9 → 290
      Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
      pfam08704
      Location:64 → 287
      GCD14; tRNA methyltransferase complex GCD14 subunit
      pfam14801
      Location:12 → 58
      GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111644539..111650336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XC2.1 GenPept UniProtKB/Swiss-Prot:Q80XC2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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