Cnep1r1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnep1r1provided by MGI
Official Full Name: CTD nuclear envelope phosphatase 1 regulatory subunit 1provided by MGI
Primary source: MGI:MGI:1921981
See related: Ensembl:ENSMUSG00000036810 AllianceGenome:MGI:1921981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NEP1-R1; Tmem188; 5033428A16Rik
Summary: Predicted to be involved in positive regulation of protein dephosphorylation; positive regulation of triglyceride biosynthetic process; and protein localization to nucleus. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Predicted to be active in cytoplasm. Orthologous to human CNEP1R1 (CTD nuclear envelope phosphatase 1 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 12.6), CNS E11.5 (RPKM 10.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 43.06 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (88845344..88861825)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (88118716..88135197)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Title: Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235960

NoName (e-PCR)
- UniSTS:493260

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Nem1-Spo7 phosphatase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Nem1-Spo7 phosphatase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear envelope phosphatase-regulatory subunit 1

Names: transmembrane protein 188

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029074.3 → NP_083350.2 nuclear envelope phosphatase-regulatory subunit 1

See identical proteins and their annotated locations for NP_083350.2

Status: VALIDATED

Source sequence(s)

AC126034, AK146578, BY124150

Consensus CDS

CCDS52628.1

UniProtKB/Swiss-Prot

A7E1Z4, Q3UJ81, Q8VEG8, Q9D3Q4

UniProtKB/TrEMBL

D3Z6J3

Related

ENSMUSP00000092839.4, ENSMUST00000095214.10

Conserved Domains (1) summary

pfam09771
Location:5 → 122

Tmemb_18A; Transmembrane protein 188

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

88845344..88861825

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248420.2 → XP_011246722.1 nuclear envelope phosphatase-regulatory subunit 1 isoform X1

UniProtKB/TrEMBL

D3Z6J3

Conserved Domains (1) summary

pfam09771
Location:5 → 112

Tmemb_18A; Transmembrane protein 188
XM_011248421.2 → XP_011246723.1 nuclear envelope phosphatase-regulatory subunit 1 isoform X2

See identical proteins and their annotated locations for XP_011246723.1

UniProtKB/TrEMBL

D3Z6J3

Related

ENSMUSP00000113207.2, ENSMUST00000117775.2

Conserved Domains (1) summary

pfam09771
Location:5 → 112

Tmemb_18A; Transmembrane protein 188