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    Wwtr1 WW domain containing transcription regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 97064, updated on 28-May-2024

    Summary

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    Official Symbol
    Wwtr1provided by MGI
    Official Full Name
    WW domain containing transcription regulator 1provided by MGI
    Primary source
    MGI:MGI:1917649
    See related
    Ensembl:ENSMUSG00000027803 AllianceGenome:MGI:1917649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Taz; 2310058J06Rik; 2610021I22Rik
    Summary
    This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
    Annotation information
    Note: Wwtr1 (Gene ID: 97064) and Taz (Gene ID: 66826) loci share the Taz symbol/alias in common. [08 Feb 2019]
    Expression
    Broad expression in bladder adult (RPKM 25.1), lung adult (RPKM 24.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wwtr1 in Genome Data Viewer
    Location:
    3 D; 3 27.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (57363065..57483331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (57455644..57575910, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52659 Neighboring gene transmembrane 4 superfamily member 4 Neighboring gene STARR-seq mESC enhancer starr_07732 Neighboring gene NEDD8-conjugating enzyme UBE2F pseudogene Neighboring gene STARR-seq mESC enhancer starr_07733 Neighboring gene STARR-seq mESC enhancer starr_07736 Neighboring gene predicted gene, 26671 Neighboring gene microRNA 6377 Neighboring gene predicted gene, 46805 Neighboring gene COMM domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD133-Src-TAZ signaling stimulates ductal fibrosis following DDC diet-induced liver injury. Oh HT, et al. J Cell Physiol, 2022 Dec. PMID 36250997
    2. Reduced expression of TAZ inhibits primary cilium formation in renal glomeruli. Jun JH, et al. Exp Mol Med, 2022 Feb. PMID 35177808, Free PMC Article
    3. TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A. Hwang JH, et al. Nat Commun, 2022 Feb 3. PMID 35115527, Free PMC Article
    4. TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands. Miyachi Y, et al. Genes Cells, 2021 Sep. PMID 34142411
    5. Tubular transcriptional co-activator with PDZ-binding motif protects against ischemic acute kidney injury. Wu CL, et al. Clin Sci (Lond), 2020 Jul 17. PMID 32558891

    See all (317) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology.
      Title: Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology.
    2. Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
      Title: Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
    3. TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis.
      Title: TAZ stimulates exercise-induced muscle satellite cell activation via Pard3-p38 MAPK-TAZ signalling axis.
    4. TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment.
      Title: TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment.
    5. Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice.
      Title: Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice.
    6. Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries.
      Title: Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries.
    7. Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta.
      Title: Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta.
    8. Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury.
      Title: Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury.
    9. Emerging Roles of YAP/TAZ in Tooth and Surrounding: from Development to Regeneration.
      Title: Emerging Roles of YAP/TAZ in Tooth and Surrounding: from Development to Regeneration.
    10. A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer.
      Title: A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (143)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (13)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesenchymal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of metanephric nephron tubule epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WW domain-containing transcription regulator protein 1
    Names
    transcriptional coactivator with PDZ-binding motif

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168281.1 → NP_001161753.1  WW domain-containing transcription regulator protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001161753.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AK009983, AK142299, AK142720, AV026487, AW457051
      Consensus CDS
      CCDS50912.1
      UniProtKB/Swiss-Prot
      Q9EPK5
      Related
      ENSMUSP00000113040.2, ENSMUST00000120977.2
      Conserved Domains (1) summary
      smart00456
      Location:182 → 213
      WW; Domain with 2 conserved Trp (W) residues

    2. NM_133784.3 → NP_598545.2  WW domain-containing transcription regulator protein 1 isoform 2

      See identical proteins and their annotated locations for NP_598545.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK009983, AK142299, AK142720, AV026487, AW457051, BY145519
      Consensus CDS
      CCDS38434.1
      UniProtKB/Swiss-Prot
      Q3UQ69, Q3UQM0, Q99KI4, Q9EPK5
      Related
      ENSMUSP00000029380.8, ENSMUST00000029380.14
      Conserved Domains (1) summary
      smart00456
      Location:125 → 156
      WW; Domain with 2 conserved Trp (W) residues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      57363065..57483331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPK5.2 GenPept UniProtKB/Swiss-Prot:Q9EPK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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