dpy-17 Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: dpy-17
Gene description: Nematode cuticle collagen N-terminal domain-containing protein
Primary source: WormBase:WBGene00001076
Locus tag: CELE_F54D8.1
See related: AllianceGenome:WB:WBGene00001076
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Used to study Marfan syndrome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See dpy-17 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 2

Sequence:: Chromosome: III; NC_003281.10 (5107330..5108492)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of the roles of dpy-31, sqt-3, and dpy-17 in nematode collagen assembly
Title: The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.
The dpy-17 encodes a collagen known to genetically interact with dpy-31, a BMP-1/Tolloid-like metalloprotease required for TGFbeta activation in mammals.
Title: DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan Syndrome.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54D8.1 (e-PCR)
- UniSTS:311778

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables structural constituent of cuticle	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IEA Inferred from Electronic Annotation more info
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nematode cuticle collagen N-terminal domain-containing protein

NP_498086.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5107330..5108492

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065685.9 → NP_498086.1 Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498086.1

Status: REVIEWED

UniProtKB/TrEMBL

Q20778

Conserved Domains (3) summary

PRK14959
Location:108 → 269

PRK14959; DNA polymerase III subunits gamma and tau; Provisional

pfam01391
Location:273 → 327

Collagen; Collagen triple helix repeat (20 copies)

smart01088
Location:4 → 56

Col_cuticle_N; Nematode cuticle collagen N-terminal domain